Reactome | SAR1 Activation And Membrane Binding

SAR1 Activation And Membrane Binding

Stable Identifier

R-HSA-203977

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        SAR1 Activation And Membrane Binding (Homo sapiens)

General

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SAR1-GDP is recruited to the ER membrane by the transmembrane GEF (Guanine nucleotide exchange factor) PREB (also known as SEC12), where it is converted to SAR1-GTP. PREB itself is recruited to ER exit sites through interaction with MIA2 (also known as CTAGE5).

Literature References

PubMed ID	Title	Journal	Year
10825291	COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites Paccaud, JP, Lin-Marq, N, Stephens, DJ, Pagano, A, Pepperkok, R	J Cell Sci	2000
25202031	Concentration of Sec12 at ER exit sites via interaction with cTAGE5 is required for collagen export Saito, K, Yamashiro, K, Tanabe, T, Shimazu, N, Katada, T, Kontani, K	J. Cell Biol.	2014
10982397	Dynamics of transitional endoplasmic reticulum sites in vertebrate cells Glick, BS, Hammond, AT	Mol Biol Cell	2000