SAR1 Activation And Membrane Binding

Stable Identifier
R-HSA-203977
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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SAR1-GDP is recruited to the ER membrane by the transmembrane GEF (Guanine nucleotide exchange factor) PREB (also known as SEC12), where it is converted to SAR1-GTP. PREB itself is recruited to ER exit sites through interaction with MIA2 (also known as CTAGE5).

Literature References
PubMed ID Title Journal Year
25202031 Concentration of Sec12 at ER exit sites via interaction with cTAGE5 is required for collagen export

Saito, K, Yamashiro, K, Shimazu, N, Tanabe, T, Kontani, K, Katada, T

J. Cell Biol. 2014
10825291 COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites

Stephens, DJ, Lin-Marq, N, Pagano, A, Pepperkok, R, Paccaud, JP

J Cell Sci 2000
10982397 Dynamics of transitional endoplasmic reticulum sites in vertebrate cells

Hammond, AT, Glick, BS

Mol Biol Cell 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of PREB [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created