Reactome | PDK4(?-411) [mitochondrial matrix]

PDK4(?-411) [mitochondrial matrix]

Stable Identifier

R-HSA-203941

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

PDK4, Pyruvate dehydrogenase kinase isoform 4

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
  - Pyruvate metabolism and Citric Acid (TCA) cycle (Homo sapiens)
    - Pyruvate metabolism (Homo sapiens)
      - Regulation of pyruvate dehydrogenase (PDH) complex (Homo sapiens)
        
        PDK isoforms phosphorylate lipo-PDH (Homo sapiens)
        
        PDK isoforms [mitochondrial matrix] (Homo sapiens)
        
        PDK4(?-411) [mitochondrial matrix] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16654 PDK4

Gene Names

PDK4, PDHK4

Chain

transit peptide:1-, chain:-411

Reference Genes

BioGPS Gene:5166 PDK4

COSMIC (genes):PDK4 PDK4

CTD Gene:5166 PDK4

dbSNP Gene:5166 PDK4

ENSEMBL:ENSG00000004799 PDK4

HGNC:8812 PDK4

KEGG Gene (Homo sapiens):5166 PDK4

Monarch:5166 PDK4

NCBI Gene:5166 PDK4

OMIM:602527 PDK4

UCSC:Q16654 PDK4

Reference Transcript

RefSeq:NM_002612.3 PDK4

Other Identifiers

0006770347

11716974_a_at

11716975_a_at

17059955

205960_at

225207_at

3062083

3062084

3062087

3062089

3062091

3062096

3062099

3062100

3062102

3062103

3062105

3062108

3062110

3062111

3062112

3062113

3062115

36739_at

48647_at

5166

8141094

A_23_P257087

A_24_P243749

GE59241

GE86339

GO:0000166

GO:0003674

GO:0004672

GO:0004740

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005737

GO:0005739

GO:0005759

GO:0005975

GO:0006006

GO:0006464

GO:0006468

GO:0006629

GO:0006790

GO:0006885

GO:0006950

GO:0007165

GO:0008150

GO:0008219

GO:0008286

GO:0009058

GO:0009267

GO:0010510

GO:0010565

GO:0010906

GO:0016301

GO:0016310

GO:0016740

GO:0034641

GO:0042304

GO:0042592

GO:0042593

GO:0042594

GO:0043167

GO:0043226

GO:0044281

GO:0045124

GO:0046320

GO:0071398

GO:0072593

GO:2000811

HMNXSV003048468

Hs.8364.0.A1_3p_at

ILMN_1684982

PH_hs_0000890

TC07001618.hg

U54617_at

g4505692_3p_at

Participates

as a member of

PDK isoforms [mitochondrial matrix] (Homo sapiens)

Inferred To

pdhk-2 [mitochondrial matrix] (Caenorhabditis elegans)

pkp1 [mitochondrial matrix] (Schizosaccharomyces pombe)

pdk4 [mitochondrial matrix] (Danio rerio)

Pdk4 [mitochondrial matrix] (Mus musculus)

Pdk4 [mitochondrial matrix] (Rattus norvegicus)

Pdk [mitochondrial matrix] (Drosophila melanogaster)

PDK4 [mitochondrial matrix] (Gallus gallus)

PDK4(?-411) [mitochondrial matrix] (Sus scrofa)

Cross References

RefSeq

NP_002603.1

Guide to Pharmacology - Targets

2144

OpenTargets

ENSG00000004799

ZINC - Substances

PDK4_HUMAN

HPA

ENSG00000004799-PDK4

GeneCards

Q16654

ZINC target

Q16654

Ensembl

ENSG00000004799, ENSP00000005178, ENST00000005178

PRO

Q16654

Pharos - Targets

Q16654

ZINC - Predictions - Purchasable

PDK4_HUMAN

PDB

2ZDY, 3D2R, 2ZKJ, 2ZDX, 2E0A