Exportin-5 recognizes 3' overhang of pre-miRNA

Stable Identifier
R-HSA-203922
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Exportin-5 binds pre-microRNAs having 2-nucleotide overhangs at the 3' end. Binding is independent of sequence and depends on GTP.

Literature References
PubMed ID Title Journal Year
14681208 Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

Yi, R, Qin, Y, Macara, IG, Cullen, BR

Genes Dev 2003
14631048 Nuclear export of microRNA precursors

Lund, E, G├╝ttinger, S, Calado, A, Dahlberg, JE, Kutay, U

Science 2004
14730017 Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs

Bohnsack, MT, Czaplinski, K, Gorlich, D

RNA 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
RNA binding activity of Ran:GTP:Exportin-5 [nucleoplasm]
Physical Entity
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