Exportin-5 recognizes 3' overhang of pre-miRNA

Stable Identifier
R-HSA-203922
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Exportin-5 recognizes 3' overhang of pre-miRNA
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Exportin-5 binds pre-microRNAs having 2-nucleotide overhangs at the 3' end. Binding is independent of sequence and depends on GTP.
Literature References
PubMed ID Title Journal Year
14631048 Nuclear export of microRNA precursors

Kutay, U, Dahlberg, JE, Lund, E, Calado, A, Güttinger, S

Science 2004
14681208 Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

Macara, IG, Yi, R, Cullen, BR, Qin, Y

Genes Dev 2003
14730017 Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs

Gorlich, D, Czaplinski, K, Bohnsack, MT

RNA 2004
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Catalyst Activity

RNA binding activity of Ran:GTP:Exportin-5 [nucleoplasm]

Physical Entity
Ran:GTP:Exportin-5 [nucleoplasm] (Homo sapiens)
Activity
RNA binding (GO:0003723)
Authored
Gopinathrao, G  (2007-11-19)
May, B  (2007-11-19)
Reviewed
Hannon, GJ  (2008-02-08)
Karginov, F  (2008-02-08)
Created
Gopinathrao, G  (2007-11-19)
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