Pol II mediated transcription of microRNA genes

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Transcription of miRNA genes. Most miRNAs are transcribed by RNA polymerase II. The miRNAs may be autonomous transcription units or they may be located in other transcripts, including locations within introns and other untranslated regions. Of the polymerase II transcribed miRNAs, about 60% are located in introns of protein coding genes, 12 % are in introns of non-coding RNAs, 18% are in exons of non-coding RNAs, and 10% uncertain.
A second class of miRNA genes are associated with Alu and other repetitive elements and are cotranscribed with these elements by RNA polymerase III. There are currently only a few proven examples of polymerase III transcribed miRNAs.
Literature References
PubMed ID Title Journal Year
15525708 Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs

Hagedorn, CH, Cai, X, Cullen, BR

RNA 2004
17099701 RNA polymerase III transcribes human microRNAs

Lanier, W, Davidson, BL, Borchert, GM

Nat Struct Mol Biol 2006
15372072 MicroRNA genes are transcribed by RNA polymerase II

Baek, SH, Kim, VN, Yeom, KH, Han, J, Lee, Y, Lee, S, Kim, M

EMBO J 2004
17057362 Intronic microRNA (miRNA)

Lin, SL, Miller, JD, Ying, SY

J Biomed Biotechnol 2006
15364901 Identification of mammalian microRNA host genes and transcription units

Bradley, A, Griffiths-Jones, S, Ashurst, JL, Rodriguez, A

Genome Res 2004
Event Information
Catalyst Activity

DNA-directed 5'-3' RNA polymerase activity of RNA Polymerase II holoenzyme complex (generic) [nucleoplasm]

Cite Us!