KIBRA (WWC1) binds LATS proteins

Stable Identifier
R-HSA-2038398
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Cytosolic KIBRA (WWC1) binds LATS proteins. The stoichiometry of the resulting complex is unlnown. The interaction of KIBRA with LATS directly or indirectly stimulates the phosphorylation of the latter proteins, so this interaction may promote LATS activation and, ultimately, YAP1 and TAZ sequestration in vivo (Xiao et al. 2011).

Literature References
PubMed ID Title Journal Year
21233212 KIBRA regulates Hippo signaling activity via interactions with large tumor suppressor kinases

Xiao, L, Chen, Y, Ji, M, Dong, J

J Biol Chem 2011
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