KIBRA (WWC1) binds LATS proteins

Stable Identifier
R-HSA-2038398
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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KIBRA (WWC1) binds LATS proteins
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Cytosolic KIBRA (WWC1) binds LATS proteins. The stoichiometry of the resulting complex is unlnown. The interaction of KIBRA with LATS directly or indirectly stimulates the phosphorylation of the latter proteins, so this interaction may promote LATS activation and, ultimately, YAP1 and TAZ sequestration in vivo (Xiao et al. 2011).
Literature References
PubMed ID Title Journal Year
21233212 KIBRA regulates Hippo signaling activity via interactions with large tumor suppressor kinases

Chen, Y, Ji, M, Dong, J, Xiao, L

J Biol Chem 2011
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Orthologous Events
KIBRA (WWC1) binds LATS proteins (Bos taurus)
KIBRA (WWC1) binds LATS proteins (Canis familiaris)
KIBRA (WWC1) binds LATS proteins (Drosophila melanogaster)
KIBRA (WWC1) binds LATS proteins (Gallus gallus)
KIBRA (WWC1) binds LATS proteins (Mus musculus)
KIBRA (WWC1) binds LATS proteins (Rattus norvegicus)
KIBRA (WWC1) binds LATS proteins (Sus scrofa)
KIBRA (WWC1) binds LATS proteins (Xenopus tropicalis)
Authored
D'Eustachio, P  (2012-02-03)
Reviewed
Sudol, M  (2012-02-03)
Created
D'Eustachio, P  (2012-01-10)
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