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DUSP3 [nucleoplasm]
Stable Identifier
R-HSA-203798
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Dual specificity protein phosphatase 3, DUS3_HUMAN, Dual specificity protein phosphatase VHR, VHR
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
ERK-specific DUSP [nucleoplasm] (Homo sapiens)
DUSP3 [nucleoplasm] (Homo sapiens)
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
DUSP3 [nucleoplasm] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
ERK-specific DUSP [nucleoplasm] (Homo sapiens)
DUSP3 [nucleoplasm] (Homo sapiens)
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
DUSP3 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
ERK-specific DUSP [nucleoplasm] (Homo sapiens)
DUSP3 [nucleoplasm] (Homo sapiens)
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
DUSP3 [nucleoplasm] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
ERK-specific DUSP [nucleoplasm] (Homo sapiens)
DUSP3 [nucleoplasm] (Homo sapiens)
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
DUSP3 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
ERK-specific DUSP [nucleoplasm] (Homo sapiens)
DUSP3 [nucleoplasm] (Homo sapiens)
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
DUSP3 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
ERK-specific DUSP [nucleoplasm] (Homo sapiens)
DUSP3 [nucleoplasm] (Homo sapiens)
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
DUSP3 [nucleoplasm] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
ERK-specific DUSP [nucleoplasm] (Homo sapiens)
DUSP3 [nucleoplasm] (Homo sapiens)
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
DUSP3 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
ERK-specific DUSP [nucleoplasm] (Homo sapiens)
DUSP3 [nucleoplasm] (Homo sapiens)
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
DUSP3 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
ERK-specific DUSP [nucleoplasm] (Homo sapiens)
DUSP3 [nucleoplasm] (Homo sapiens)
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
DUSP3 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
ERK-specific DUSP [nucleoplasm] (Homo sapiens)
DUSP3 [nucleoplasm] (Homo sapiens)
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
DUSP3 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERKs are inactivated (Homo sapiens)
ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
ERK-specific DUSP [nucleoplasm] (Homo sapiens)
DUSP3 [nucleoplasm] (Homo sapiens)
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
DUSP3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51452 DUSP3
Gene Names
DUSP3, VHR
Chain
chain:1-185
Reference Genes
BioGPS Gene:1845 DUSP3
COSMIC (genes):DUSP3 DUSP3
CTD Gene:1845 DUSP3
dbSNP Gene:1845 DUSP3
ENSEMBL:ENSG00000108861 DUSP3
ENSEMBL_homo_sapiens_GENE:ENSG00000108861.9 DUSP3
HGNC:3069 DUSP3
KEGG Gene (Homo sapiens):1845 DUSP3
Monarch:1845 DUSP3
NCBI Gene:1845 DUSP3
OMIM:600183 DUSP3
UCSC:P51452 DUSP3
Reference Transcript
RefSeq:NM_004090.3 DUSP3
Other Identifiers
11733776_a_at
11733777_a_at
11733778_x_at
11733779_a_at
11748476_a_at
11753617_a_at
11757791_s_at
16845445
1845
201536_PM_at
201536_at
201537_PM_s_at
201537_s_at
201538_PM_s_at
201538_s_at
275_at
3758616
3758617
3758618
3758619
3758620
3758621
3758622
3758623
3758624
3758625
3758626
3758627
3758630
3758633
3758634
41225_at
41226_at
8015835
A_23_P129956
A_23_P400255
GE572498
GE62149
GO:0000278
GO:0001772
GO:0002376
GO:0003824
GO:0004721
GO:0004722
GO:0004725
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006470
GO:0007155
GO:0008092
GO:0008138
GO:0016311
GO:0016787
GO:0016791
GO:0017018
GO:0019901
GO:0023052
GO:0030336
GO:0030971
GO:0033549
GO:0034330
GO:0035335
GO:0036211
GO:0042059
GO:0043226
GO:0043409
GO:0045931
GO:0046329
GO:0048870
GO:0050860
GO:0050868
GO:0050922
GO:0051893
GO:0070373
GO:0071364
GO:0120183
GO:0140096
GO:1990264
GO:1990782
HMNXSV003050333
Hs.181046.0.A3_3p_at
ILMN_1797522
L05147_at
PH_hs_0029350
TC17001563.hg
g12803692_3p_a_at
g4758207_3p_a_at
Participates
as a component of
VRK3:DUSP3 [nucleoplasm] (Homo sapiens)
as a member of
ERK-specific DUSP [nucleoplasm] (Homo sapiens)
Inferred To
MKP-like [nucleoplasm]
(Drosophila melanogaster)
Dusp3 [nucleoplasm]
(Mus musculus)
Dusp3 [nucleoplasm]
(Rattus norvegicus)
dusp3a [nucleoplasm]
(Danio rerio)
DUSP3 [nucleoplasm]
(Bos taurus)
DUSP3 [nucleoplasm]
(Canis familiaris)
DUSP3 [nucleoplasm]
(Gallus gallus)
DUSP3 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_004081.1
OpenTargets
ENSG00000108861
ZINC - Substances
DUS3_HUMAN
ZINC target
P51452
PRO
P51452
PDB
1VHR
,
3F81
,
1J4X
IntEnz
3.1.3.16
GeneCards
P51452
HPA
ENSG00000108861-DUSP3
Ensembl
ENSP00000226004
,
ENSG00000108861
,
ENST00000226004
Pharos - Targets
P51452
ZINC - Predictions - Purchasable
DUS3_HUMAN
HMDB Protein
HMDBP08910
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