Reactome | Interaction of Csk with PAG

Interaction of Csk with PAG

Stable Identifier

R-HSA-203774

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Csk is a tyrosine kinase that phosphorylates the negative regulatory C-terminal tyrosine residue Y505 of Lck to maintain Lck in an inactive state. In resting T cells, Csk is targeted to lipid rafts through engagement of its SH2 domain with phosphotyrosine residue pY317 of PAG. PAG is expressed as a tyrosine phosphorylated protein in nonstimulated T-cells. This interaction of Csk and PAG allows activation of Csk and inhibition of Lck. Given that PAG-1 T cell knock out show a weak phenotype, some other protein may substitute in activating Csk.

Literature References

PubMed ID	Title	Journal	Year
12938237	The activation of Csk by CD4 interferes with TCR-mediated activatory signaling Tuosto, L, Marinari, B, Piccolella, E, Simeoni, L, Schraven, B	Eur J Immunol	2003
10790433	Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation Shevchenko, A, Korinek, V, Bruyns, E, Scherer, J, Hilgert, I, Brdicka, T, Cerny, J, Horejsi, V, Kornacker, B, Leo, A, Angelisova, P, Pavlistova, D, Schraven, B, Drbal, K, Kuramitsu, Y	J Exp Med	2000