Reactome | WWTR1 (TAZ) binds TEAD

WWTR1 (TAZ) binds TEAD

Stable Identifier

R-HSA-2032781

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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In the nucleus the WWTR1 (TAZ) transcriptional coactivator can bind any one of the four TEAD transcription factors to form a complex. The stoichiometry of this complex is unknown (Chan et al. 2009; Zhang et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19324877	TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition Lei, Q, Guan, KL, Xiong, Y, Liu, CY, Zhang, H, Zhao, B, Zha, ZY, Yao, J, Zhao, S	J Biol Chem	2009
19324876	TEADs mediate nuclear retention of TAZ to promote oncogenic transformation Lim, CJ, Hong, W, Loo, LS, Huang, C, Chan, SW, Chong, YF	J Biol Chem	2009