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Platelet-derived TREM-1 ligand binds to TREM-1
Stable Identifier
R-HSA-203156
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Platelet-derived TREM-1 ligand binds to TREM-1 (Homo sapiens)
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The triggering receptor expressed on myeloid cells 1 (TREM-1) plays an important role in the innate immune response related to severe infections and sepsis. Although the identity and occurrence of the natural TREM-1 ligands are so far unknown, the presence of a ligand for TREM-1 on human platelets has been established. It has been suggested that TREM1 recognizes soluble proteins or cell-surface proteins which are upregulated as a result of inflammation and/or tissue damage and also bacterial LPS (Tessarz & Cerwenka 2008).
Literature References
PubMed ID
Title
Journal
Year
17452516
TREM-1 ligand expression on platelets enhances neutrophil activation
Haselmayer, P
,
Schild, H
,
von Landenberg, P
,
Radsak, MP
,
Grosse-Hovest, L
Blood
2007
Participants
Input
Ligand to TREM-1 on the platelet membrane [plasma membrane]
TREM1 [plasma membrane]
(Homo sapiens)
Output
TREM-1 bound to its ligand [plasma membrane]
(Homo sapiens)
Participates
as an event of
Cell surface interactions at the vascular wall (Homo sapiens)
Orthologous Events
Platelet-derived TREM-1 ligand binds to TREM-1 (Bos taurus)
Platelet-derived TREM-1 ligand binds to TREM-1 (Canis familiaris)
Platelet-derived TREM-1 ligand binds to TREM-1 (Mus musculus)
Platelet-derived TREM-1 ligand binds to TREM-1 (Rattus norvegicus)
Platelet-derived TREM-1 ligand binds to TREM-1 (Sus scrofa)
Authored
Ouwehand, WH (2007-11-12)
Reviewed
Zwaginga, JJ (2007-11-12)
Created
de Bono, B (2007-11-12)
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