Platelet-derived TREM-1 ligand binds to TREM-1

Stable Identifier
R-HSA-203156
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The triggering receptor expressed on myeloid cells 1 (TREM-1) plays an important role in the innate immune response related to severe infections and sepsis. Although the identity and occurrence of the natural TREM-1 ligands are so far unknown, the presence of a ligand for TREM-1 on human platelets has been established. It has been suggested that TREM1 recognizes soluble proteins or cell-surface proteins which are upregulated as a result of inflammation and/or tissue damage and also bacterial LPS (Tessarz & Cerwenka 2008).

Literature References
PubMed ID Title Journal Year
17452516 TREM-1 ligand expression on platelets enhances neutrophil activation Blood 2007
Participants
Participant Of
Orthologous Events