Reactome | Association of profilin with monomeric actin

Association of profilin with monomeric actin

Stable Identifier

R-HSA-203070

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Association of profilin with monomeric actin

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Profilins PFN1 and PFN2 bind to monomeric actin (G-actin), forming a 1:1 complex and subsequently regulate actin filament barbed end assembly downstream of various signaling pathways (Pring et al. 1992, Korenbaum et al. 1998, Nodelman et al. 1999)

Literature References

PubMed ID	Title	Journal	Year
10600384	X-ray structure determination of human profilin II: A comparative structural analysis of human profilins Nodelman, IM, Bowman, GD, Lindberg, U, Schutt, CE	J Mol Biol	1999
1737036	Profilin-actin complexes directly elongate actin filaments at the barbed end Pring, M, Weber, A, Bubb, MR	Biochemistry	1992
9649308	The role of profilin in actin polymerization and nucleotide exchange Korenbaum, E, Nordberg, P, Björkegren-Sjögren, C, Schutt, CE, Lindberg, U, Karlsson, R	Biochemistry	1998