Fcgamma receptor (FCGR) dependent phagocytosis

Stable Identifier
Homo sapiens
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Phagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phagocytosis is a complex process involving the recognition of invading foreign particles by specific types of phagocytic receptors and the subsequent internalization of the particles. Fc gamma receptors (FCGRs) are among the best studied phagocytic receptors that bind to Fc portion of immunoglobulin G (IgG). Through their antigen binding F(ab) end, antibodies bind to specific antigen while their constant (Fc) region binds to FCGRs on phagocytes. The clustering of FCGRs by IgG antibodies on the phagocyte initiates a variety of signals, which lead, through the reorganisation of actin cytoskeleton and membrane remodelling, to the formation of pseudopod and phagosome. Fc gamma receptors are classified into three classes: FCGRI, FCGRII and FCGRIII. Each class of these FCGRs consists of several individual isoforms. Among all these isoforms FCGRI, FCGRIIA and FCGRIIIA, are able to mediate phagocytosis (Joshi et al. 2006, Garcia Garcia & Rosales 2002, Nimmerjahn & Ravetch 2006).
Literature References
PubMed ID Title Journal Year
16413920 Fcgamma receptors: old friends and new family members

Ravetch, JV, Nimmerjahn, F

Immunity 2006
12488490 Signal transduction during Fc receptor-mediated phagocytosis

Rosales, C, García-García, E

J Leukoc Biol 2002
17050193 Fcgamma receptor signaling in phagocytes

Tridandapani, S, Joshi, T, Butchar, JP

Int J Hematol 2006
8541526 The molecular dissection of Fc gamma receptor mediated phagocytosis

Indik, ZK, Hunter, S, Schreiber, AD, Park, JG

Blood 1995
Event Information
Orthologous Events
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