Reactome | CDH1(155-750) [plasma membrane]

CDH1(155-750) [plasma membrane]

Stable Identifier

R-HSA-202940

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Epithelial-cadherin precursor fragment (155-750), CAD1_HUMAN, CDH1

Locations in the PathwayBrowser for interactor UniProt:Q96EF9 ZHX1R

Expand all

External Reference Information

External Reference

UniProt:P12830 CDH1

Gene Names

CDH1, CDHE, UVO

Chain

signal peptide:1-22, propeptide:23-154, chain:155-882, chain:701-882, chain:732-882, chain:751-882

Reference Genes

BioGPS Gene:999 CDH1

COSMIC (genes):CDH1 CDH1

CTD Gene:999 CDH1

dbSNP Gene:999 CDH1

ENSEMBL:ENSG00000039068 CDH1

ENSEMBL_homo_sapiens_GENE:ENSG00000039068.20 CDH1

HGNC:1748 CDH1

KEGG Gene (Homo sapiens):999 CDH1

Monarch:999 CDH1

NCBI Gene:999 CDH1

OMIM:192090 CDH1

UCSC:P12830 CDH1

Reference Transcript

Other Identifiers

11716905_a_at

11716906_a_at

16820486

201130_PM_s_at

201130_s_at

201131_PM_s_at

201131_s_at

2082_s_at

3666410

3666411

3666412

3666427

3666430

3666431

3666432

3666433

3666435

3666437

3666438

3666442

3666444

3666445

3666450

3666451

3666452

3666453

3666454

3666455

3666459

7996837

977_s_at

999

A_23_P206359

GE57732

GO:0000902

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005768

GO:0005794

GO:0005802

GO:0005856

GO:0005886

GO:0005912

GO:0006351

GO:0006355

GO:0006886

GO:0006913

GO:0007043

GO:0007155

GO:0007156

GO:0007416

GO:0008013

GO:0008092

GO:0009410

GO:0009636

GO:0009898

GO:0010033

GO:0010468

GO:0015629

GO:0016020

GO:0016328

GO:0016339

GO:0016342

GO:0016600

GO:0021983

GO:0022408

GO:0023052

GO:0030027

GO:0030054

GO:0030154

GO:0030163

GO:0030336

GO:0030506

GO:0030517

GO:0030864

GO:0031175

GO:0031410

GO:0032794

GO:0034330

GO:0034332

GO:0042307

GO:0042802

GO:0043226

GO:0043296

GO:0044331

GO:0045295

GO:0045296

GO:0045893

GO:0046872

GO:0048471

GO:0048856

GO:0048870

GO:0050839

GO:0070062

GO:0070161

GO:0071285

GO:0071681

GO:0072659

GO:0098609

GO:0098794

GO:0098978

GO:0099576

GO:0140459

GO:1990782

HMNXSV003039550

ILMN_1770940

PH_hs_0011491

TC16000559.hg

Z35402_rna1_s_at

g340184_3p_a_at

g4757959_3p_a_at

Participates

as a component of

E-cadherin strand dimer fragment 155-750 [plasma membrane] (Homo sapiens)

as an output of

Caspase-mediated cleavage of E-Cadherin (Homo sapiens)

Other forms of this molecule

CDH1(732-882) [plasma membrane]

CDH1(155-700) [plasma membrane]

CDH1(701-882) [extracellular region]

Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane]

p-Y753,Y754-CDH1(155-882) [plasma membrane]

CDH1(751-882) [plasma membrane]

CDH1(155-882) [plasma membrane]

Inferred To

CDH1 [plasma membrane] (Bos taurus)

CDH1 [plasma membrane] (Canis familiaris)

CDH1 [plasma membrane] (Sus scrofa)

CDH1(155-750) [plasma membrane] (Canis familiaris)

CDH1(155-750) [plasma membrane] (Danio rerio)

CDH1(155-750) [plasma membrane] (Gallus gallus)

CDH1(155-750) [plasma membrane] (Mus musculus)

CDH1(155-750) [plasma membrane] (Rattus norvegicus)

CadN2 [plasma membrane] (Drosophila melanogaster)

Homologues of CDH1(155-750) [plasma membrane] (Canis familiaris)

Cross References

RefSeq

NP_001304113.1, NP_004351.1, NP_001304115.1, NP_001304114.1

OpenTargets

ENSG00000039068

HPA

ENSG00000039068-CDH1

GeneCards

P12830

Ensembl

ENSP00000414946, ENST00000422392, ENSP00000261769, ENSG00000039068, ENST00000261769

PRO

P12830

Pharos - Targets

P12830

Orphanet

15419

HMDB Protein

HMDBP02891

PDB

2OMZ, 6OLF, 2OMT, 7STZ, 6VEL, 2OMU, 3L6X, 3FF7, 3L6Y, 1O6S, 3FF8, 2OMV, 6OLG, 4ZTE, 2OMX, 8H62, 2O72, 6CXY, 4ZT1, 6OLE, 2OMY

Interactors (51)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.962	23
UniProt:P12830 CDH1	8	CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.875	7
UniProt:P35221 CTNNA1	2	CTNNA1 [cytosol] (R-HSA-191697) CTNNA1 [plasma membrane] (R-HSA-191735)	0.803	8
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.735	4
UniProt:O60716 CTNND1	1	CTNND1 [plasma membrane] (R-HSA-418996)	0.731	9
UniProt:Q6IQ23 PKHA7			0.695	5
UniProt:P0DJM0 inlA	1	InlA [peptidoglycan-based cell wall] (R-LMO-8876505)	0.683	3
UniProt:Q9JIY2	1	Cbll1 [cytosol] (R-MMU-8851646)	0.645	21
UniProt:P30260 CDC27	2	CDC27 [nucleoplasm] (R-HSA-174175) CDC27 [cytosol] (R-HSA-174073)	0.589	2
UniProt:Q15139 PRKD1	1	PRKD1 [cytosol] (R-HSA-58210)	0.571	7
UniProt:P49768 PSEN1	6	PSEN1(1-467) [plasma membrane] (R-HSA-201606) PSEN1(299-467) [azurophil granule membrane] (R-HSA-6799234) PSEN1(1-467) [azurophil granule membrane] (R-HSA-6799235) PSEN1(1-298) [azurophil granule membrane] (R-HSA-6799209) PSEN1(1-298) [plasma membrane] (R-HSA-2534298) PSEN1(299-467) [plasma membrane] (R-HSA-2534245)	0.564	2
UniProt:Q96EF9 ZHX1R			0.556	3
UniProt:P17612 PRKACA	4	PRKACA [mitochondrial matrix] (R-HSA-9838291) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [cytosol] (R-HSA-57844)	0.556	3
UniProt:O94983-5 CAMTA2			0.556	3
UniProt:Q9HC98-4 NEK6			0.556	3
UniProt:Q02978 SLC25A11	1	SLC25A11 [mitochondrial inner membrane] (R-HSA-198451)	0.556	3
UniProt:P49184 DNASE1L1	2	DNASE1L1 [extracellular region] (R-HSA-6806320) DNASE1L1 [specific granule lumen] (R-HSA-6799554)	0.556	3
UniProt:Q9BT49 THAP7			0.556	3
UniProt:Q9Y617 PSAT1	1	PXLP-K200-PSAT1 [cytosol] (R-HSA-977330)	0.556	3
UniProt:Q9BQ29 Q9BQ29			0.556	3
UniProt:Q8TB02 Q8TB02			0.556	3
UniProt:P43356 MAGA2			0.556	3
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.556	3
UniProt:Q9ULW0 TPX2	2	TPX2 [cytosol] (R-HSA-8853407) TPX2 [nucleoplasm] (R-HSA-2564700)	0.556	3
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.556	3
UniProt:P16422 EPCAM	1	EPCAM [plasma membrane] (R-HSA-375068)	0.556	3
UniProt:Q8NBT0 POC1A			0.556	3
UniProt:P48775 TDO2	1	TDO2 [cytosol] (R-HSA-71184)	0.556	3
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.556	3
UniProt:Q96QH2 PRAM			0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.556	3
UniProt:Q8NCR3 MFI			0.556	3
IntAct:EBI-25833683 CCSB			0.556	3
UniProt:Q9NPC7 MYNN			0.556	3
UniProt:Q8N323 NXPE1			0.556	3
UniProt:Q6UXH1-2 CRELD2			0.556	3
UniProt:Q7Z6Z7-2 HUWE1			0.556	3
UniProt:P11362 FGFR1	9	FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 R576W [plasma membrane] (R-HSA-2011844) p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) FGFR1 [plasma membrane] (R-HSA-9756433)	0.536	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	8
UniProt:Q9UN70 PCDGK			0.527	2
UniProt:Q9UI47 CTNA3			0.527	3
UniProt:P33724	5	CAV1 [endocytic vesicle membrane] (R-CFA-535009) CAV1 [lipid droplet] (R-CFA-163510) CAV1 [early endosome membrane] (R-CFA-5368451) CAV1 [plasma membrane] (R-CFA-534994) CAV1 [Golgi membrane] (R-CFA-204504)	0.525	2
UniProt:P02511 CRYAB	1	CRYAB [nucleoplasm] (R-HSA-6806336)	0.524	2
UniProt:cagA A0A2X5ABY1			0.524	2
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.524	2
UniProt:O43707 ACTN4	3	ACTN4 [cytosol] (R-HSA-390558) ACTN4 [platelet alpha granule lumen] (R-HSA-198240) ACTN4 [extracellular region] (R-HSA-349729)	0.499	2
UniProt:Q68CZ2 TNS3	1	TNS3 [cytosol] (R-HSA-8875524)	0.499	2
UniProt:Q9H8V3 ECT2	1	ECT2 [cytosol] (R-HSA-195036)	0.499	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.499	2
UniProt:P12931 SRC	6	p-Y419-SRC [nucleoplasm] (R-HSA-8937690) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.499	2
UniProt:A0A0S2C3P2 A0A0S2C3P2			0.463	3

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