Release of PLCG from FCGR

Stable Identifier
R-HSA-2029272
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
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Release of PLCG from FCGR
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Activated PLCG translocates to the plasmamembrane and interacts with the inositol ring of the membrane bound phosphatidylinositol 4,5-bisphosphate (PIP2) with its PH domain. The active enzyme promotes intracelllular signaling by catalysing the hydrolysis of PIP2 to generate the second messengers IP3 and DAG.

Literature References
PubMed ID Title Journal Year
10579907 Phospholipase C-gamma as a signal-transducing element

Carpenter, G, Ji, Q

Exp Cell Res 1999
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Authored
Garapati, P V  (2012-01-04)
Reviewed
Rosales, C  (2012-05-15)
Created
Garapati, P V  (2012-01-04)
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