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Release of PLCG from FCGR
Stable Identifier
R-HSA-2029272
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Role of phospholipids in phagocytosis (Homo sapiens)
Release of PLCG from FCGR (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Activated PLCG translocates to the plasmamembrane and interacts with the inositol ring of the membrane bound phosphatidylinositol 4,5-bisphosphate (PIP2) with its PH domain. The active enzyme promotes intracelllular signaling by catalysing the hydrolysis of PIP2 to generate the second messengers IP3 and DAG.
Literature References
PubMed ID
Title
Journal
Year
10579907
Phospholipase C-gamma as a signal-transducing element
Ji, Q
,
Carpenter, G
Exp Cell Res
1999
Participants
Input
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane]
(Homo sapiens)
Output
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane]
(Homo sapiens)
p-PLCG [plasma membrane]
(Homo sapiens)
PI(3,4,5)P3 [plasma membrane]
Participates
as an event of
Role of phospholipids in phagocytosis (Homo sapiens)
Orthologous Events
Release of PLCG from FCGR (Bos taurus)
Release of PLCG from FCGR (Canis familiaris)
Release of PLCG from FCGR (Gallus gallus)
Release of PLCG from FCGR (Mus musculus)
Release of PLCG from FCGR (Rattus norvegicus)
Release of PLCG from FCGR (Sus scrofa)
Authored
Garapati, P V (2012-01-04)
Reviewed
Rosales, C (2012-05-15)
Created
Garapati, P V (2012-01-04)
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