AMOT (130 KDa isoform) and AMOTL1 can each bind WWTR1 (TAZ) and sequester it in the cytosol. AMOTL2 - WWTR1 binding has not been studied but is inferred to occur from the presence of key binding sequence motifs in AMOTL2 protein and from its known binding activity with YAP1, a WWTR1 homolog. These interactions are not dependent on WWTR1 phosphorylation and may thus be a means of negatively regulating WWTR1 activity in addition to the ones dependent on Hippo pathway-dependent phosphorylation. AMOT - WWTR1 binding is dependent on sequence motifs in the amino terminal portions of the AMOT proteins (and that are absent from the AMOT 80 KDa isoform) (Chan et al. 2011).
Chan, SW, Lim, CJ, Chong, YF, Pobbati, AV, Huang, C, Hong, W
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