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AMOT proteins bind WWTR1 (TAZ)
Stable Identifier
R-HSA-2028735
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
Signaling by Hippo (Homo sapiens)
AMOT proteins bind WWTR1 (TAZ) (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
AMOT (130 KDa isoform) and AMOTL1 can each bind WWTR1 (TAZ) and sequester it in the cytosol. AMOTL2 - WWTR1 binding has not been studied but is inferred to occur from the presence of key binding sequence motifs in AMOTL2 protein and from its known binding activity with YAP1, a WWTR1 homolog. These interactions are not dependent on WWTR1 phosphorylation and may thus be a means of negatively regulating WWTR1 activity in addition to the ones dependent on Hippo pathway-dependent phosphorylation. AMOT - WWTR1 binding is dependent on sequence motifs in the amino terminal portions of the AMOT proteins (and that are absent from the AMOT 80 KDa isoform) (Chan et al. 2011).
Literature References
PubMed ID
Title
Journal
Year
21224387
Hippo pathway-independent restriction of TAZ and YAP by angiomotin
Pobbati, AV
,
Lim, CJ
,
Hong, W
,
Huang, C
,
Chan, SW
,
Chong, YF
J Biol Chem
2011
Participants
Input
AMOT proteins [cytosol]
(Homo sapiens)
WWTR1 [cytosol]
(Homo sapiens)
Output
AMOT:WWTR1 (TAZ) [cytosol]
(Homo sapiens)
Participates
as an event of
Signaling by Hippo (Homo sapiens)
Orthologous Events
AMOT proteins bind WWTR1 (TAZ) (Bos taurus)
AMOT proteins bind WWTR1 (TAZ) (Canis familiaris)
AMOT proteins bind WWTR1 (TAZ) (Danio rerio)
AMOT proteins bind WWTR1 (TAZ) (Gallus gallus)
AMOT proteins bind WWTR1 (TAZ) (Mus musculus)
AMOT proteins bind WWTR1 (TAZ) (Rattus norvegicus)
AMOT proteins bind WWTR1 (TAZ) (Sus scrofa)
AMOT proteins bind WWTR1 (TAZ) (Xenopus tropicalis)
Authored
D'Eustachio, P (2012-02-03)
Reviewed
Sudol, M (2012-02-03)
Created
D'Eustachio, P (2012-01-04)
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