Cleavage of p-STK4 (p-MST1) by caspase 3

Stable Identifier
R-HSA-2028692
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic caspase 3 cleaves p-STK4 (p-MST1) to yield an active animo-terminal fragment (p-STK4/N) and a carboxy-terminal fragment (p-STK4/C) (Graves et al. 1998; Lee et al. 2001). The association of p-STK4 (p-MST1) with other proteins at the time of its cleavage by caspase has not been studied experimentally. Here, it is inferred to be dimerized and in a complex with SAV1 because that is the form of the molecule that becomes phosphorylated and phosphorylation appears normally to precede caspase cleavage. The effect of the cleavage is to increase the kinase activity of p-STK4 (p-MST1).

Literature References
PubMed ID Title Journal Year
9545236 Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1

Graves, JD, Gotoh, Y, Draves, KE, Ambrose, DM, Han, DK, Wright, M, Chernoff, J, Clark, EA, Krebs, EG

EMBO J 1998
11278283 MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation

Lee, KK, Ohyama, T, Yajima, N, Tsubuki, S, Yonehara, S

J Biol Chem 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
Physical Entity
Activity
Orthologous Events
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Created