Reactome | Cleavage of p-STK4 (p-MST1) by caspase 3

Cleavage of p-STK4 (p-MST1) by caspase 3

Stable Identifier

R-HSA-2028692

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Cleavage of p-STK4 (p-MST1) by caspase 3

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic caspase 3 cleaves p-STK4 (p-MST1) to yield an active animo-terminal fragment (p-STK4/N) and a carboxy-terminal fragment (p-STK4/C) (Graves et al. 1998; Lee et al. 2001). The association of p-STK4 (p-MST1) with other proteins at the time of its cleavage by caspase has not been studied experimentally. Here, it is inferred to be dimerized and in a complex with SAV1 because that is the form of the molecule that becomes phosphorylated and phosphorylation appears normally to precede caspase cleavage. The effect of the cleavage is to increase the kinase activity of p-STK4 (p-MST1).

Literature References

PubMed ID	Title	Journal	Year
11278283	MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation Tsubuki, S, Yajima, N, Lee, KK, Ohyama, T, Yonehara, S	J Biol Chem	2001
9545236	Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1 Ambrose, DM, Krebs, EG, Han, DK, Gotoh, Y, Clark, EA, Draves, KE, Chernoff, J, Wright, M, Graves, JD	EMBO J	1998