Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N

Stable Identifier
R-HSA-2028679
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic LATS1 and LATS2 are phosphorylated by phospho-STK4(MST1)/N (Graves et al. 1998; Lee et al. 2001). LATS proteins are known to form complexes with MOB1 proteins and this reaction is annotated with LATS:MOB1 complexes as its substrate. Serine-909 and threonine-1097 have been identified as LATS1 residues phosphorylated by STK4 (MST1) kinase. The target residues of LATS2 have not been identified experiemntally but are inferred to be serine-871 and threonine-1041 based on sequence similarity.

Literature References
PubMed ID Title Journal Year
9545236 Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1

Graves, JD, Gotoh, Y, Draves, KE, Ambrose, DM, Han, DK, Wright, M, Chernoff, J, Clark, EA, Krebs, EG

EMBO J 1998
11278283 MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation

Lee, KK, Ohyama, T, Yajima, N, Tsubuki, S, Yonehara, S

J Biol Chem 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-STK4/N:p-SAV1 [cytosol]
Physical Entity
Activity
Orthologous Events
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