Reactome | Phosphorylation of MOB1A and B by p-STK4(MST1)/N

Phosphorylation of MOB1A and B by p-STK4(MST1)/N

Stable Identifier

R-HSA-2028670

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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Phosphorylation of MOB1A and B by p-STK4(MST1)/N

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Cytosolic MOB1A and MOB1B are phosphorylated by phospho-STK4(MST1)/N (Graves et al. 1998; Lee et al. 2001). Threonine residues 12 and 35 have been experimentally identifed as the targets of MOB1A phosphorylation; the homologous residues of MOB1B are inferred likewise to be targets.

Literature References

PubMed ID	Title	Journal	Year
9545236	Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1 Graves, JD, Gotoh, Y, Draves, KE, Ambrose, DM, Han, DK, Wright, M, Chernoff, J, Clark, EA, Krebs, EG	EMBO J	1998
11278283	MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation Lee, KK, Ohyama, T, Yajima, N, Tsubuki, S, Yonehara, S	J Biol Chem	2001