Phosphorylation of WWTR1 (TAZ) by LATS2

Stable Identifier
Reaction [transition]
Homo sapiens
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Cytosolic phospho-LATS2, complexed with MOB1, catalyzes the phosphorylation of WWTR1 (TAZ) on serine residue 89 (Lei et al. 2008). This reaction is positively regulated by the angiomotin proteins AMOT (130 kd form), AMOTL1, and AMOTL2, which may function by physically bridging LATS2 and YAP (Zhao et al. 2011).

Literature References
PubMed ID Title Journal Year
18227151 TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway

Lei, Q, Guan, KL, Xiong, Y, Pei, XH, Zhang, H, Zha, ZY, Zhao, B, Bai, F, Zhao, S

Mol Cell Biol 2008
21205866 Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

Lei, Q, Guan, KL, Liu, CY, Li, L, Wang, LH, Lu, Q, Zhao, B

Genes Dev 2011
Catalyst Activity

protein serine/threonine kinase activity of p-LATS2:p-MOB1 [cytosol]

This event is regulated
Positively by