Phosphorylation of MOB1A and B by p-STK4 (p-MST1)

Stable Identifier
R-HSA-2028629
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Phosphorylation of MOB1A and B by p-STK4 (p-MST1)
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Cytosolic MOB1A and MOB1B are phosphorylated by phospho-STK4 (p-MST1). Phosphorylated (active) STK4 (p-MST1) and SAV1 are known to form a complex and that complex is annotated as the catalyst of this reaction. Threonine residues 12 and 35 have been experimentally identifed as the targets of MOB1A phosphorylation; the homologous residues of MOB1B are inferred likewise to be targets (Praskova et al. 2008).
Literature References
PubMed ID Title Journal Year
18328708 MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation

Praskova, M, Xia, F, Avruch, J

Curr Biol 2008
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Catalyst Activity

protein serine/threonine kinase activity of p-STK4:p-SAV1 [cytosol]

Physical Entity
p-STK4:p-SAV1 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Bos taurus)
Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Caenorhabditis elegans)
Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Canis familiaris)
Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Drosophila melanogaster)
Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Gallus gallus)
Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Mus musculus)
Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Rattus norvegicus)
Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Sus scrofa)
Phosphorylation of MOB1A and B by p-STK4 (p-MST1) (Xenopus tropicalis)
Authored
D'Eustachio, P  (2012-02-03)
Reviewed
Sudol, M  (2012-02-03)
Created
D'Eustachio, P  (2011-12-30)
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