Phosphorylation of MOB1A and B by p-STK4 (p-MST1)

Stable Identifier
R-HSA-2028629
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic MOB1A and MOB1B are phosphorylated by phospho-STK4 (p-MST1). Phosphorylated (active) STK4 (p-MST1) and SAV1 are known to form a complex and that complex is annotated as the catalyst of this reaction. Threonine residues 12 and 35 have been experimentally identifed as the targets of MOB1A phosphorylation; the homologous residues of MOB1B are inferred likewise to be targets (Praskova et al. 2008).

Literature References
PubMed ID Title Journal Year
18328708 MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation

Praskova, M, Xia, F, Avruch, J

Curr Biol 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-STK4:p-SAV1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created