Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)

Stable Identifier
R-HSA-2028555
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Cytosolic LATS1 and LATS2 are phosphorylated by phospho-STK4 (p-MST1). LATS proteins are known to form complexes with MOB1 proteins and this reaction is annotated with LATS:MOB1 complexes as its substrate. Likewise, phosphorylated (active) STK4 (p-MST1) and SAV1 are known to form a complex and that complex is annotated as the catalyst of this reaction. Serine-909 and threonine-1079 have been identified as LATS1 residues phosphorylated by STK4 (MST1) kinase. The target residues of LATS2 have not been identified experimentally but are inferred to be serine-872 and threonine-1041 based on sequence similarity (Chan et al. 2005).
Literature References
PubMed ID Title Journal Year
15688006 The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

Chalamalasetty, RB, Nigg, EA, Nousiainen, M, Chan, EH, Silljé, HH, Schäfer, A

Oncogene 2005
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-STK4:p-SAV1 [cytosol]

Orthologous Events
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