Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)

Stable Identifier
R-HSA-2028555
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic LATS1 and LATS2 are phosphorylated by phospho-STK4 (p-MST1). LATS proteins are known to form complexes with MOB1 proteins and this reaction is annotated with LATS:MOB1 complexes as its substrate. Likewise, phosphorylated (active) STK4 (p-MST1) and SAV1 are known to form a complex and that complex is annotated as the catalyst of this reaction. Serine-909 and threonine-1097 have been identified as LATS1 residues phosphorylated by STK4 (MST1) kinase. The target residues of LATS2 have not been identified experimentally but are inferred to be serine-871 and threonine-1041 based on sequence similarity (Chan et al. 2005).

Literature References
PubMed ID Title Journal Year
15688006 The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

Chan, EH, Nousiainen, M, Chalamalasetty, RB, Schäfer, A, Nigg, EA, Silljé, HH

Oncogene 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-STK4:p-SAV1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created