Reactome | p-S127-YAP1 [cytosol]

p-S127-YAP1 [cytosol]

Stable Identifier

R-HSA-2028553

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p1-YAP1, monophospho-YAP1

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Locations in the PathwayBrowser for interactor UniProt:O14669 TMG2

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Literature References

PubMed ID	Title	Journal	Year
17974916	Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control Zhao, B, Wei, X, Li, W, Udan, RS, Yang, Q, Kim, J, Xie, J, Ikenoue, T, Yu, J, Li, L, Zheng, P, Ye, K, Chinnaiyan, A, Halder, G, Lai, ZC, Guan, KL	Genes Dev	2007

External Reference Information

External Reference

UniProt:P46937 YAP1

Gene Names

YAP1, YAP65

Chain

chain:1-504

Reference Genes

BioGPS Gene:10413 YAP1

COSMIC (genes):YAP1 YAP1

CTD Gene:10413 YAP1

dbSNP Gene:10413 YAP1

ENSEMBL:ENSG00000137693 YAP1

HGNC:16262 YAP1

KEGG Gene (Homo sapiens):10413 YAP1

Monarch:10413 YAP1

NCBI Gene:10413 YAP1

OMIM:606608 YAP1

UCSC:P46937 YAP1

Reference Transcript

Other Identifiers

0006350706

10413

11717920_a_at

11717921_x_at

11717922_a_at

11717923_s_at

11717924_a_at

11717925_s_at

11740548_a_at

11746496_a_at

16730503

213342_at

224894_at

224895_at

2929983

3346452

3346454

3346455

3346456

3346457

3346458

3346460

3346461

3346468

3346479

3346489

3346492

3346498

3346504

3346508

3346509

3346510

37979_at

46314_at

7943398

A_14_P102030

A_23_P104762

A_24_P273679

GE60063

GO:0000902

GO:0000976

GO:0000978

GO:0001570

GO:0001894

GO:0002376

GO:0003013

GO:0003015

GO:0003143

GO:0003674

GO:0003677

GO:0003682

GO:0003713

GO:0003714

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005667

GO:0005737

GO:0005829

GO:0006367

GO:0006950

GO:0006974

GO:0007165

GO:0007267

GO:0008022

GO:0008134

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0009058

GO:0009790

GO:0010468

GO:0010628

GO:0010629

GO:0010837

GO:0016020

GO:0022607

GO:0030154

GO:0030216

GO:0030857

GO:0030903

GO:0032570

GO:0032991

GO:0033148

GO:0034641

GO:0035019

GO:0035329

GO:0040007

GO:0042060

GO:0042127

GO:0042592

GO:0043226

GO:0045747

GO:0045893

GO:0045944

GO:0046622

GO:0048339

GO:0048368

GO:0048856

GO:0050679

GO:0050767

GO:0050847

GO:0060045

GO:0060242

GO:0060449

GO:0060487

GO:0060576

GO:0060828

GO:0061026

GO:0065003

GO:0070064

GO:0070102

GO:0071148

GO:0071149

GO:0071300

GO:0071480

GO:0072091

GO:0072307

GO:0090263

GO:0140297

GO:1902036

GO:1902459

GO:1903507

GO:1904036

GO:2000737

GO:2001237

Hs.84520.0.S1_3p_at

Hs.84520.0.S2_3p_at

Hs.8939.0.A2_3p_at

ILMN_1672821

ILMN_1709479

PH_hs_0022813

TC11000954.hg

X80507_at

Participant Of

output

Phosphorylation of YAP by LATS2

hasMember

p-YAP1 [cytosol]

Other forms of this molecule

p-Y407-YAP1 [nucleoplasm]

p-Y-YAP1 [cytosol]

p-Y-YAP1 [nucleoplasm]

p-5S-YAP1 [cytosol]

YAP1 [nucleoplasm]

YAP1 [cytosol]

Inferred To

phospho-yap1 [cytosol] (Danio rerio)

phospho-YAP1 [cytosol] (Gallus gallus)

phospho-YAP1 [cytosol] (Sus scrofa)

phospho-yap-1 [cytosol] (Caenorhabditis elegans)

phospho-Yap1 [cytosol] (Mus musculus)

phospho-Yap1 [cytosol] (Rattus norvegicus)

phospho-p-S127-YAP1 [cytosol] (Bos taurus)

Modified Residues

Name

O-phospho-L-serine at 127

Coordinate

127

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001181973.1, NP_001269030.1, NP_001269027.1, NP_001269026.1, NP_001181974.1, NP_001269029.1, NP_001269028.1, NP_001123617.1

OpenTargets

ENSG00000137693

HPA

ENSG00000137693-YAP1

GeneCards

P46937

Ensembl

ENST00000524575, ENSG00000137693, ENSP00000435602, ENST00000629586, ENST00000615667, ENSP00000478927, ENSP00000487519, ENST00000345877, ENSP00000434134, ENSP00000331023, ENSP00000445635, ENST00000282441, ENST00000537274, ENSP00000431574, ENST00000531439, ENSP00000282441, ENST00000526343

PRO

P46937

Orphanet

22672

PDB

6G8Q, 5YDY, 1K5R, 6GEI, 6G8P, 6GE4, 5OAQ, 3MHR, 1K9Q, 6GE3, 6GEG, 2LAY, 2LAX, 6GEK, 2LTV, 6GEC, 6G8L, 4RE1, 6GEE, 1K9R, 5YDX, 4REX, 1JMQ, 6Q2X, 6G8K, 2LTW, 3KYS, 6HIL, 6GE5, 6HIK, 2LAW, 6G8I, 6GE6, 6G6X, 6G8J

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28347 TEAD1	1	TEAD1 [nucleoplasm] (R-HSA-2032774)	0.937	10
UniProt:P35222 CTNNB1	33	CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) Ub-K,p-Y-CTNNB1 [cytosol] (R-HSA-8877006) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1 [nucleoplasm] (R-HSA-3451168)	0.881	14
UniProt:Q15561 TEAD4	1	TEAD4 [nucleoplasm] (R-HSA-2032780)	0.863	10
UniProt:O95835 LATS1	2	p-S909,T1097-LATS1 [cytosol] (R-HSA-2028551) LATS1 [cytosol] (R-HSA-2028562)	0.829	9
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.823	6
UniProt:Q4VCS5 AMOT			0.813	6
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.813	5
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.803	9
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.802	6
UniProt:Q15678 PTPN14	1	PTPN14 [nucleoplasm] (R-HSA-9008917)	0.759	7
UniProt:Q969T9 WBP2			0.759	7
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.758	6
UniProt:Q15599 NHRF2			0.751	5
UniProt:P97764 WBP1			0.74	13
UniProt:O15105 SMAD7	2	SMAD7 [cytosol] (R-HSA-173478) SMAD7 [nucleoplasm] (R-HSA-178197)	0.715	7
UniProt:Q15562 TEAD2	1	TEAD2 [nucleoplasm] (R-HSA-2032763)	0.71	5
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.708	5
UniProt:Q8IY63 AMOTL1	1	AMOTL1 [cytosol] (R-HSA-2028603)	0.69	5
UniProt:Q9Y2J4 AMOTL2	1	AMOTL2 [cytosol] (R-HSA-2028606)	0.69	5
UniProt:Q13625 TP53BP2	1	TP53BP2 [nucleoplasm] (R-HSA-6799780)	0.69	5
UniProt:O14745 NHRF1			0.676	8
UniProt:O14669 TMG2			0.658	5
UniProt:O15350-1 TP73			0.65	7
UniProt:Q92841 DDX17	2	SUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104) DDX17 [nucleoplasm] (R-HSA-3900090)	0.649	7
UniProt:Q99594 TEAD3	1	TEAD3 [nucleoplasm] (R-HSA-2032767)	0.643	4
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.643	3
UniProt:Q13625-2 TP53BP2			0.618	9
UniProt:O75970 MPDZ			0.597	4
UniProt:Q8N3R9 MPP5	1	MPP5 [plasma membrane] (R-HSA-419969)	0.597	4
UniProt:Q8NI35 PATJ	1	INADL [plasma membrane] (R-HSA-420011)	0.597	4
UniProt:Q13131 PRKAA1	3	PRKAA1 [cytosol] (R-HSA-380935) p-T183-PRKAA1 [cytosol] (R-HSA-380964) p-T183-PRKAA1 [nucleoplasm] (R-HSA-2151206)	0.564	3
UniProt:Q99593 TBX5	1	TBX5 [nucleoplasm] (R-HSA-2032786)	0.558	4
UniProt:Q02750 MAP2K1	27	MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) MAP2K1 Q56P [cytosol] (R-HSA-9652064) MAP2K1 E203K [cytosol] (R-HSA-9652023) MAP2K1 V60E [cytosol] (R-HSA-9652067) MAP2K1 P124S [cytosol] (R-HSA-9652062) MAP2K1 Y130C [cytosol] (R-HSA-9652101) MAP2K1 C121S [cytosol] (R-HSA-9652013) MAP2K1 G128V [cytosol] (R-HSA-9652047) MAP2K1 F53L [cytosol] (R-HSA-9652031) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 E44_E57del [cytosol] (R-HSA-9652026) MAP2K1 P124Q [cytosol] (R-HSA-9652058) MAP2K1 F53C [cytosol] (R-HSA-9652028) p-S,218, S222,T292 MAP2K1 [cytosol] (R-HSA-5674490) MAP2K1 [cytosol] (R-HSA-59502) p-T286,T292-MAP2K1 [cytosol] (R-HSA-112374) p-S218,S222,T286,T292-MAP2K1 [cytosol] (R-HSA-112339) p-S218,S222-MAP2K1 [cytosol] (R-HSA-109837)	0.556	3
UniProt:Q15562-2 TEAD2			0.556	3
UniProt:Q9Y297 BTRC	2	BTRC [nucleoplasm] (R-HSA-3361753) BTRC [cytosol] (R-HSA-174237)	0.547	2
UniProt:Q15797 SMAD1	4	SMAD1 [cytosol] (R-HSA-201468) Ub-SMAD1 [cytosol] (R-HSA-6782768) p-S463,S465-SMAD1 [cytosol] (R-HSA-201464) p-S463,S465-SMAD1 [nucleoplasm] (R-HSA-201483)	0.544	3
UniProt:Q9Y4G8 RAPGEF2	1	RAPGEF2 [cytosol] (R-HSA-5672599)	0.527	2
UniProt:Q9NUP9 LIN7C	3	LIN7C [plasma membrane] (R-HSA-5216165) LIN7C [plasma membrane] (R-HSA-6794238) LIN7C [transport vesicle membrane] (R-HSA-9610411)	0.527	3
UniProt:A6NKD9 CC85C			0.527	3
UniProt:P35240 NF2	1	NF2 [plasma membrane] (R-HSA-5669168)	0.527	2
UniProt:O35625 Axin1	8	Axin1 [cytosol] (R-MMU-4641133) Phospho Axin1 [cytosol] (R-MMU-206175) phospho-Axin1 [cytosol] (R-MMU-3640864) phospho-Axin1 [cytosol] (R-MMU-3640841) Axin1 [cytosol] (R-MMU-205727) Phospho (3 sites) Axin1 [cytosol] (R-MMU-205737) phospho-Axin1 [cytosol] (R-MMU-206040) Axin1 [cytosol] (R-MMU-195249)	0.524	3
UniProt:O14544 SOCS6	1	SOCS6 [cytosol] (R-HSA-1469969)	0.524	2
UniProt:O15169 AXIN1	11	AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) AXIN1 [cytosol] (R-HSA-195249) p-T519,S524,S531-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864)	0.499	11
IntAct:EBI-9253952 SUPER			0.462	3

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