Reactome | Phosphorylation of STK4 (MST1) and SAV1 by STK4

Phosphorylation of STK4 (MST1) and SAV1 by STK4

Stable Identifier

R-HSA-2028284

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Phosphorylation of STK4 (MST1) and SAV1 by STK4

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The serine/threonine kinase STK4 (MST1) catalyzes its own autophosphorylation as well as the phosphorylation of SAV1. These two reactions are annotated here as a single concerted process that takes place in a tetrameric complex containing two STK4 (MST1) subunits and two SAV1 subunits, based on the observations that STK4 (MST1) can catalyze both phosphorylation reactions in vitro, as well as the observations that each protein dimerizes and that STK4 (MST1) and SAV1 associate to form a complex. The order in which the various components associate, the stoichiometry of the complex ultimately formed, and the point(s) in this association process at which phosphoryltion occurs have not been established in vitro or in vivo, however (Callus et al. 2006; Creasy et al. 1996; Praskova et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15109305	Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras Praskova, M, Khoklatchev, A, Ortiz-Vega, S, Avruch, J	Biochem J	2004
8702870	The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain Creasy, CL, Ambrose, DM, Chernoff, J	J Biol Chem	1996
16930133	Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation Callus, BA, Verhagen, AM, Vaux, DL	FEBS J	2006