CD48 binds CD244

Stable Identifier
Reaction [binding]
Homo sapiens
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CD2, CD48, CD84, CD244 and CD58 have a similar extracellular domain arichitecture consisting of two IgSF domains. CD244 is closely related to CD84 in having a long cytoplasmic tail with tyrosine-based motifs (TxYxxI/V) resembling immunoreceptor tyrosine-based inhibitory motifs (ITIMs). CD2 has a cytoplasmic domain with proline-rich regions which recruit an Src homology 3 (SH3)- containing protein called CD2-associated protein (CD2AP). CD48 is glycosyl-phosphatidyl-inositol (GPI)-anchored to the membrane.

CD244 is known to be activated by binding to CD48 in humans.

Literature References
PubMed ID Title Journal Year
16585556 CD48 stimulation by 2B4 (CD244)-expressing targets activates human NK cells

Messmer, B, Eissmann, P, Stark, S, Watzl, C

J Immunol 2006
10764623 The CD2-subset of the Ig superfamily of cell surface molecules: receptor-ligand pairs expressed by NK cells and other immune cells

Tangye, SG, Phillips, JH, Lanier, LL

Semin Immunol 2000
Participant Of
Orthologous Events
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