Reactome | CD48 binds CD244

CD48 binds CD244

Stable Identifier

R-HSA-202722

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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CD2, CD48, CD84, CD244 and CD58 have a similar extracellular domain arichitecture consisting of two IgSF domains. CD244 is closely related to CD84 in having a long cytoplasmic tail with tyrosine-based motifs (TxYxxI/V) resembling immunoreceptor tyrosine-based inhibitory motifs (ITIMs). CD2 has a cytoplasmic domain with proline-rich regions which recruit an Src homology 3 (SH3)- containing protein called CD2-associated protein (CD2AP). CD48 is glycosyl-phosphatidyl-inositol (GPI)-anchored to the membrane.

CD244 is known to be activated by binding to CD48 in humans.

Literature References

PubMed ID	Title	Journal	Year
10764623	The CD2-subset of the Ig superfamily of cell surface molecules: receptor-ligand pairs expressed by NK cells and other immune cells Lanier, LL, Phillips, JH, Tangye, SG	Semin Immunol	2000
16585556	CD48 stimulation by 2B4 (CD244)-expressing targets activates human NK cells Eissmann, P, Watzl, C, Messmer, B, Stark, S	J Immunol	2006