Reactome | Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A)

Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A)

Stable Identifier

R-HSA-202718

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

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Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A)

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JAM-A plays a key role in leukocyte transmigration and inflammatory extravasation. Transmigration of human leukocytes has been shown to involve heterophilic interactions of JAM-A with its integrin receptor LFA-1.

Literature References

PubMed ID	Title	Journal	Year
15528364	The functional interaction of the beta 2 integrin lymphocyte function-associated antigen-1 with junctional adhesion molecule-A is mediated by the I domain Fraemohs, L, Koenen, RR, Ostermann, G, Heinemann, B, Weber, C	J Immunol	2004
15681301	Involvement of JAM-A in mononuclear cell recruitment on inflamed or atherosclerotic endothelium: inhibition by soluble JAM-A Ostermann, G, Fraemohs, L, Baltus, T, Schober, A, Lietz, M, Zernecke, A, Liehn, EA, Weber, C	Arterioscler Thromb Vasc Biol	2005
11812992	JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes Ostermann, G, Weber, KS, Zernecke, A, Schroder, A, Weber, C	Nat Immunol	2002
17525755	The role of junctional adhesion molecules in vascular inflammation Weber, C, Fraemohs, L, Dejana, E	Nat Rev Immunol	2007