Heterodimerization of CEACAMs

Stable Identifier
R-HSA-202717
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The presence of CEACAM dimers was shown to lead to an increase in the binding of the integrin alph5 beta1 receptor to its ligand fibronectin, without changing its cell surface levels, resulting in increased adhesion of these cells to fibronectin.

Literature References
PubMed ID Title Journal Year
17167768 GPI-anchored CEA family glycoproteins CEA and CEACAM6 mediate their biological effects through enhanced integrin alpha5beta1-fibronectin interaction

Ordonez, C, Zhai, AB, Camacho-Leal, P, Demarte, L, Fan, MM, Stanners, CP

J Cell Physiol 2007
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