Reactome | CD84 homodimerises

CD84 homodimerises

Stable Identifier

R-HSA-202713

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CD84 is a homophilic receptor expressed on T cells, B cells, dendritic cells, monocytes, macrophages, eosinophils, mast cells, granulocytes, and platelets. CD84 expression increases following activation of T cells, B cells, and dendritic cells. CD84 homophilic engagement is known to induce platelet stimulation.

Literature References

PubMed ID	Title	Journal	Year
11564780	CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1 Martin, M, Romero, X, de la Fuente, MA, Tovar, V, Zapater, N, Esplugues, E, Pizcueta, P, Bosch, J, Engel, P	J Immunol	2001
17563375	Structure of CD84 provides insight into SLAM family function Yan, Q, Malashkevich, VN, Fedorov, A, Fedorov, E, Cao, E, Lary, JW, Cole, JL, Nathenson, SG, Almo, SC	Proc Natl Acad Sci U S A	2007