Reactome | CD84 homodimerises

CD84 homodimerises

Stable Identifier

R-HSA-202713

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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CD84 is a homophilic receptor expressed on T cells, B cells, dendritic cells, monocytes, macrophages, eosinophils, mast cells, granulocytes, and platelets. CD84 expression increases following activation of T cells, B cells, and dendritic cells. CD84 homophilic engagement is known to induce platelet stimulation.

Literature References

PubMed ID	Title	Journal	Year
11564780	CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1 Tovar, V, Romero, X, de la Fuente, MA, Pizcueta, P, Esplugues, E, Zapater, N, Engel, P, Martin, M, Bosch, J	J Immunol	2001
17563375	Structure of CD84 provides insight into SLAM family function Lary, JW, Nathenson, SG, Cole, JL, Cao, E, Fedorov, A, Almo, SC, Fedorov, E, Malashkevich, VN, Yan, Q	Proc Natl Acad Sci U S A	2007