Several guanine exchange factors (GEFs) for the Rho family of GTPases contain PH domains that bind to PIP3. RhoA protein activation is a mechanism whereby PI3K acts independently of AKT (Chong et al. 1994, Oude Weernink et al. 1997).
Chong, LD, Traynor-Kaplan, A, Bokoch, GM, Schwartz, MA
Oude Weernink, PA, López de Jesús, M, Schmidt, M
Hanna, S, El-Sibai, M
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