PIP3 binds to RhoA and activates it

Stable Identifier
R-HSA-202692
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Several guanine exchange factors (GEFs) for the Rho family of GTPases contain PH domains that bind to PIP3. RhoA protein activation is a mechanism whereby PI3K acts independently of AKT (Chong et al. 1994, Oude Weernink et al. 1997).

Literature References
PubMed ID Title Journal Year
7954816 The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

Chong, LD, Traynor-Kaplan, A, Bokoch, GM, Schwartz, MA

Cell 1994
17245604 Phospholipase D signaling: orchestration by PIP2 and small GTPases

Oude Weernink, PA, López de Jesús, M, Schmidt, M

Naunyn Schmiedebergs Arch Pharmacol 2007
23669310 Signaling networks of Rho GTPases in cell motility

Hanna, S, El-Sibai, M

Cell. Signal. 2013
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created