Formation of a heteromeric BMP receptor complex

Stable Identifier
Reaction [binding]
Homo sapiens
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BMP receptors, unlike TGF-beta receptors are known to form hetero-oligomeric complexes in the endoplasmic reticulum and are transported as oligomers to the plasma membrane where they bind ligand. However, evidence for ligand-induced heteromeric BMP receptor complexes on the cell surface has also been published, leading to a model where both pre-formed and ligand-induced receptor oligomers are encountered on the plasma membrane. Based on the latter, a theory has been formulated that suggests that the signaling outcome from pre-formed and ligand-induced BMP receptor complexes is different. The mechanism that might explain this theory must involve different ways of internalization and trafficking of the BMP receptor complexes.

Literature References
PubMed ID Title Journal Year
10712517 Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors

Nohe, A, Geissendorfer, T, Knaus, P, Henis, YI, Sebald, W, Gilboa, L

Mol Biol Cell 2000
16672363 Structure of the ternary signaling complex of a TGF-beta superfamily member

Choe, S, Allendorph, GP, Vale, WW

Proc Natl Acad Sci U S A 2006
11714695 The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways

Neubauer, F, Ehrlich, M, Nohe, A, Knaus, P, Henis, YI, Sebald, W, Hassel, S

J Biol Chem 2002
Event Information
Orthologous Events
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