Calcineurin binds NFATC1,2,3

Stable Identifier
R-HSA-2025890
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Calcineurin binds NFATC1,2,3
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Calcium activates calcineurin in two ways: binding the regulatory subunit of calcineurin directly and binding calmodulin which then interacts with the catalytic subunit of calcineurin. As inferred from mouse, B lymphocytes contain the R1 regulatory subunit (PPP3R1) and the beta catalytic subunit (PPP3CB).
In the presence of calcium and calcium:calmodulin calcineurin binds phosphorylated and unphosphorylated NFATs at 2 regions in the N-terminus (Luo et al. 1996, Garcia-Cozar et al. 1998, Park et al. 2000, evidence from mouse in Loh et al. 1996 and Wesselborg et al. 1996). Calcineurin also weakly interacts with NFATs in the absence of calcium (Garcia-Cozar et al. 1998).
Literature References
PubMed ID Title Journal Year
8631904 Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity

Loh, C, Shaw, KT, Carew, J, Viola, JP, Luo, C, Perrino, BA, Rao, A

J Biol Chem 1996
8576111 Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp)

Wesselborg, S, Fruman, DA, Sagoo, JK, Bierer, BE, Burakoff, SJ

J Biol Chem 1996
10860980 A second calcineurin binding site on the NFAT regulatory domain

Park, S, Uesugi, M, Verdine, GL

Proc Natl Acad Sci U S A 2000
8799126 Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import

Luo, C, Shaw, KT, Raghavan, A, Aramburu, J, Garcia-Cozar, F, Perrino, BA, Hogan, PG, Rao, A

Proc Natl Acad Sci U S A 1996
9727000 Two-site interaction of nuclear factor of activated T cells with activated calcineurin

Garcia-Cozar, FJ, Okamura, H, Aramburu, JF, Shaw, KT, Pelletier, L, Showalter, R, Villafranca, E, Rao, A

J Biol Chem 1998
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Orthologous Events
Calcineurin binds NFATC1,2,3 (Bos taurus)
Calcineurin binds NFATC1,2,3 (Canis familiaris)
Calcineurin binds NFATC1,2,3 (Drosophila melanogaster)
Calcineurin binds NFATC1,2,3 (Mus musculus)
Calcineurin binds NFATC1,2,3 (Rattus norvegicus)
Authored
May, B  (2011-12-11)
Reviewed
Wienands, J  (2012-02-12)
Created
May, B  (2011-12-20)
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