Reactome | B4GALTs transfer Gal to the N-glycan precursor

B4GALTs transfer Gal to the N-glycan precursor

Stable Identifier

R-HSA-2025723

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

ReviewStatus

5/5

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B4GALTs transfer Gal to the N-glycan precursor

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B4GALTs transfer galactose (Gal) from UDP-Gal to the N-glycan modified core protein (Wu et al., 2023). The family of beta 4-galactosyltransferases (B4GALTs) is composed of at least six known members with different Km and acceptor specificities (Guo et al. 2001) that probably originated by gene duplication (Lo et al. 1998). They mediate the transfer of galactose to high-mannose N-glycan structures which initiate the beginning of keratan sulfate (KS) biosynthesis. B4GALT1 is associated with Congenital Disorder of Glycosylation of type IId (MIM:607091) (Hansske et al. 2002), and is expressed as two splicing isoforms of which only one is localized in the Golgi system (Lopez et al. 1991, Schaub et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
38034954	Exploiting Substrate Specificities of 6-O-Sulfotransferases to Enzymatically Synthesize Keratan Sulfate Oligosaccharides Wu, Y, Vos, GM, Huang, C, Chapla, D, Kimpel, ALM, Moremen, KW, de Vries, RP, Boons, GJ	JACS Au	2023
17021253	Transition of galactosyltransferase 1 from trans-Golgi cisterna to the trans-Golgi network is signal mediated Schaub, BE, Berger, B, Berger, EG, Rohrer, J	Mol Biol Cell	2006
11901181	Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId Hansske, B, Thiel, C, Lübke, T, Hasilik, M, Höning, S, Peters, V, Heidemann, PH, Hoffmann, GF, Berger, EG, von Figura, K, Körner, C	J Clin Invest	2002
11588157	Galactosylation of N-linked oligosaccharides by human beta-1,4-galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells Guo, S, Sato, T, Shirane, K, Furukawa, K	Glycobiology	2001
1714903	Evidence for a molecular distinction between Golgi and cell surface forms of beta 1,4-galactosyltransferase Lopez, LC, Youakim, A, Evans, SC, Shur, BD	J Biol Chem	1991
9597550	The expanding beta 4-galactosyltransferase gene family: messages from the databanks Lo, NW, Shaper, JH, Pevsner, J, Shaper, NL	Glycobiology	1998