Activation of TAK1-TAB2 complex

Stable Identifier
R-HSA-202510
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Ubiquitinated TRAF6 recruits TAB2 and activates the TAB2-associated TAK1 kianse by promoting the autophosphorylation of TAK1. TAB2 contains an N-term pseudophosphatase domain, which is indispensable for TAK1 activation, and a C-term domain that binds to and activates TAK1. The activation of TAK1/TAB2 complex requires a ubiquitination reaction catalysed by E1, Ubc13/Uev1A (E2) and TRAF6 (E3). TAK1 undergoes autophosphorylation on residues T184 and T187 and gets activated. Activated TAK1 then phosphorylates and activates IKK beta.

Literature References
PubMed ID Title Journal Year
17496917 Ubiquitin-mediated activation of TAK1 and IKK

Adhikari, A, Xu, M, Chen, ZJ

Oncogene 2007
16056267 Ubiquitin signalling in the NF-kappaB pathway

Chen, ZJ

Nat Cell Biol 2005
15125833 The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

Sun, L, Deng, L, Ea, CK, Xia, ZP, Chen, ZJ

Mol Cell 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of TAB2/TAK1 complex [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created