Reactome | Activation of TAK1-TAB2 complex

Activation of TAK1-TAB2 complex

Stable Identifier

R-HSA-202510

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Ubiquitinated TRAF6 recruits TAB2 and activates the TAB2-associated TAK1 kianse by promoting the autophosphorylation of TAK1. TAB2 contains an N-term pseudophosphatase domain, which is indispensable for TAK1 activation, and a C-term domain that binds to and activates TAK1. The activation of TAK1/TAB2 complex requires a ubiquitination reaction catalysed by E1, Ubc13/Uev1A (E2) and TRAF6 (E3). TAK1 undergoes autophosphorylation on residues T184 and T187 and gets activated. Activated TAK1 then phosphorylates and activates IKK beta.

Literature References

PubMed ID	Title	Journal	Year
16056267	Ubiquitin signalling in the NF-kappaB pathway Chen, ZJ	Nat Cell Biol	2005
17496917	Ubiquitin-mediated activation of TAK1 and IKK Xu, M, Adhikari, A, Chen, ZJ	Oncogene	2007
15125833	The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes Deng, L, Chen, ZJ, Sun, L, Xia, ZP, Ea, CK	Mol Cell	2004