Phosphorylation of Bcl10

Stable Identifier
R-HSA-202459
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phosphorylation of Bcl10
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Upon interaction with CARMA1, Bcl10 undergoes phosphorylation and oligomerization. The oligomerized Bcl10 acts as a adaptor for the incoming MALT1 and TRAF6. Phosphorylation events of Bcl10 can both positively and negatively regulate the NF-kB pathway. Phosphorylation of Bcl10 that depends on the Ser/Thr kinase RIP2 and correlated with the physical association of Bcl10 with RIP2 has a activation effect on the NF-kB pathway. The target sites of RIP2-mediated phosphorylation has not yet been identified.
Literature References
PubMed ID Title Journal Year
17468049 Post-translational modifications regulate distinct functions of CARMA1 and BCL10

Weil, R, Thome, M

Trends Immunol 2007
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of RIPK2 [cytosol]

Physical Entity
RIPK2 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of Bcl10 (Bos taurus)
Phosphorylation of Bcl10 (Canis familiaris)
Phosphorylation of Bcl10 (Gallus gallus)
Phosphorylation of Bcl10 (Mus musculus)
Phosphorylation of Bcl10 (Rattus norvegicus)
Phosphorylation of Bcl10 (Sus scrofa)
Authored
Garapati, P V  (2008-01-24)
Rudd, C.E.  (2008-01-24)
de Bono, B  (2008-01-24)
Reviewed
Trowsdale, J  (2008-02-26)
Created
Garapati, P V  (2007-10-30)
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