Phosphorylation of Bcl10

Stable Identifier
R-HSA-202459
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Phosphorylation of Bcl10
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Upon interaction with CARMA1, Bcl10 undergoes phosphorylation and oligomerization. The oligomerized Bcl10 acts as a adaptor for the incoming MALT1 and TRAF6. Phosphorylation events of Bcl10 can both positively and negatively regulate the NF-kB pathway. Phosphorylation of Bcl10 that depends on the Ser/Thr kinase RIP2 and correlated with the physical association of Bcl10 with RIP2 has a activation effect on the NF-kB pathway. The target sites of RIP2-mediated phosphorylation has not yet been identified.

Literature References
PubMed ID Title Journal Year
17468049 Post-translational modifications regulate distinct functions of CARMA1 and BCL10

Thome, M, Weil, R

Trends Immunol 2007
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of RIPK2 [cytosol]
Physical Entity
RIPK2 [cytosol]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
Phosphorylation of Bcl10 (Bos taurus)
Phosphorylation of Bcl10 (Canis familiaris)
Phosphorylation of Bcl10 (Mus musculus)
Phosphorylation of Bcl10 (Xenopus tropicalis)
Authored
Rudd, C.E.  (2008-01-24)
de Bono, B  (2008-01-24)
Garapati, P V  (2008-01-24)
Reviewed
Trowsdale, J  (2008-02-26)
Created
Garapati, P V  (2007-10-30)