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TCR signaling
Stable Identifier
R-HSA-202403
DOI
10.3180/react_12526.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
TCR signaling (Homo sapiens)
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The TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen presenting cells (APCs) results in the activation of protein tyrosine kinases (PTKs) that associate with CD3 and TCR zeta subunits and the co-receptor CD4. Members of the Src kinases (Lck), Syk kinases (ZAP-70), Tec (Itk) and Csk families of nonreceptor PTKs play a crucial role in T cell activation. Activation of PTKs following TCR engagement results in the recruitment and tyrosine phosphorylation of enzymes such as phospholipase C gamma1 and Vav as well as critical adaptor proteins such as LAT, SLP-76 and Gads. These proximal activation leads to reorganization of the cytoskeleton as well as transcription activation of multiple genes leading to T lymphocyte proliferation, differentiation and/or effector function.
Literature References
PubMed ID
Title
Journal
Year
9989491
Adaptors and molecular scaffolds in immune cell signaling
Rudd, CE
Cell
1999
12876557
Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling
Schneider, H
,
Rudd, CE
Nat Rev Immunol
2003
10375551
T cell antigen-receptor signal transduction
van Leeuwen, JE
,
Samelson, LE
Curr Opin Immunol
1999
Participants
Events
Phosphorylation of CD3 and TCR zeta chains
(Homo sapiens)
Translocation of ZAP-70 to Immunological synapse
(Homo sapiens)
Generation of second messenger molecules
(Homo sapiens)
Downstream TCR signaling
(Homo sapiens)
Participates
as an event of
Adaptive Immune System (Homo sapiens)
Event Information
Go Biological Process
T cell receptor signaling pathway (0050852)
Orthologous Events
TCR signaling (Bos taurus)
TCR signaling (Caenorhabditis elegans)
TCR signaling (Canis familiaris)
TCR signaling (Danio rerio)
TCR signaling (Dictyostelium discoideum)
TCR signaling (Drosophila melanogaster)
TCR signaling (Gallus gallus)
TCR signaling (Mus musculus)
TCR signaling (Plasmodium falciparum)
TCR signaling (Rattus norvegicus)
TCR signaling (Saccharomyces cerevisiae)
TCR signaling (Schizosaccharomyces pombe)
TCR signaling (Sus scrofa)
TCR signaling (Xenopus tropicalis)
Authored
Garapati, P V (2008-01-24)
Rudd, C.E. (2008-01-24)
de Bono, B (2008-01-24)
Reviewed
Trowsdale, J (2008-02-26)
Created
Garapati, P V (2007-10-29)
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