Activation of Lck

Stable Identifier
R-HSA-202291
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Activation of Lck
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The binding of CD4/CD8 to non-polymorphic regions of MHC brings Lck in to proximity with TCR subunits phosphorylation. Lck is further phosphorylated to promote the active conformation and to increase their catalytic activity. The C-term domain contain a regulatory activation loop, which is the site of activating Tyr 394 phosphorylation. This tyrosine is auto-phosphorylated to attain an active conformation on TCR stimulation. Now Lck through its kinase activity phosphorylates the ITAMs in TCR zeta and CD3 members.

Literature References
PubMed ID Title Journal Year
15489916 Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

Palacios, EH, Weiss, A

Oncogene 2004
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane]
Physical Entity
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
Activation of Lck (Bos taurus)
Activation of Lck (Canis familiaris)
Activation of Lck (Mus musculus)
Activation of Lck (Rattus norvegicus)
Activation of Lck (Sus scrofa)
Activation of Lck (Xenopus tropicalis)
Authored
Rudd, C.E.  (2008-01-24)
de Bono, B  (2008-01-24)
Garapati, P V  (2008-01-24)
Reviewed
Trowsdale, J  (2008-02-26)
Created
Garapati, P V  (2007-10-29)