ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)

Stable Identifier
R-HSA-2022399
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
ENPEP:zn2+ Hydrolyzes Angiotensin II to Yield Angiotensin III
ReviewStatus
5/5
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ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)
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Aminopeptidase A (APA, ENPEP) hydrolyzes the N-terminal amino acid of angiotensin-(1-8) (angiotensin II) to yield angiotensin-(2-8) (angiotensin III) (Goto et al. 2006). The catalysis is more specific and efficient in the presence of calcium ions (Goto et al. 2006).
Literature References
PubMed ID Title Journal Year
16790432 Enzymatic properties of human aminopeptidase A. Regulation of its enzymatic activity by calcium and angiotensin IV

Tsujimoto, M, Ishii, Y, Goto, Y, Hattori, A, Mizutani, S

J Biol Chem 2006
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Output
Participates
as an event of
Event Information
Go Biological Process
angiotensin maturation (0002003)
Catalyst Activity

metallopeptidase activity of ENPEP:Zn2+ dimer [plasma membrane]

Physical Entity
ENPEP:Zn2+ dimer [plasma membrane] (Homo sapiens)
Activity
metallopeptidase activity (GO:0008237)
Orthologous Events
ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Bos taurus)
ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Caenorhabditis elegans)
ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Canis familiaris)
ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Drosophila melanogaster)
ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Gallus gallus)
ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Mus musculus)
ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Rattus norvegicus)
ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Sus scrofa)
ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Xenopus tropicalis)
Authored
May, B  (2011-11-19)
Reviewed
Joseph, J  (2012-08-06)
Created
May, B  (2011-11-29)
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