ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)

Stable Identifier
R-HSA-2022399
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
ENPEP Hydrolyzes Angiotensin II to Yield Angiotensin III
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Aminopeptidase A (APA, ENPEP) hydrolyzes the N-terminal amino acid of angiotensin-(1-8) (angiotensin II) to yield angiotensin-(2-8) (angiotensin III) (Goto et al. 2006). The catalysis is more specific and efficient in the presence of calcium ions (Goto et al. 2006).

Literature References
PubMed ID Title Journal Year
16790432 Enzymatic properties of human aminopeptidase A. Regulation of its enzymatic activity by calcium and angiotensin IV

Goto, Y, Hattori, A, Ishii, Y, Mizutani, S, Tsujimoto, M

J Biol Chem 2006
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Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
metallopeptidase activity of ENPEP Dimer [plasma membrane]
Physical Entity
Activity
Orthologous Events
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