ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)

Stable Identifier
R-HSA-2022399
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
ENPEP Hydrolyzes Angiotensin II to Yield Angiotensin III
ReviewStatus
5/5
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ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)
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Aminopeptidase A (APA, ENPEP) hydrolyzes the N-terminal amino acid of angiotensin-(1-8) (angiotensin II) to yield angiotensin-(2-8) (angiotensin III) (Goto et al. 2006). The catalysis is more specific and efficient in the presence of calcium ions (Goto et al. 2006).

Literature References
PubMed ID Title Journal Year
16790432 Enzymatic properties of human aminopeptidase A. Regulation of its enzymatic activity by calcium and angiotensin IV

Tsujimoto, M, Ishii, Y, Goto, Y, Hattori, A, Mizutani, S

J Biol Chem 2006
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
angiotensin maturation (0002003)
Catalyst Activity

metallopeptidase activity of ENPEP Dimer [plasma membrane]

Physical Entity
ENPEP Dimer [plasma membrane] (Homo sapiens)
Activity
metallopeptidase activity (GO:0008237)
Orthologous Events
ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Bos taurus)
ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Canis familiaris)
ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Danio rerio)
ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Gallus gallus)
ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Mus musculus)
ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Rattus norvegicus)
ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Sus scrofa)
Authored
May, B  (2011-11-19)
Reviewed
Joseph, J  (2012-08-06)
Created
May, B  (2011-11-29)
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