Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)

Stable Identifier
R-HSA-2022383
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Chymase Hydrolyzes Angiotensin I to Yield Angiotensin II
ReviewStatus
5/5
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Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)
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Chymase hydrolyzes angiotensin-(1-10) (angiotensin) to yield angiotensin-(1-8) (angiotensin II) at a higher rate than does angiotensin-converting enzyme (Reilly et al. 1982, Urata et al. 1990, Caughey et al. 2000, Richard et al. 2001).
Literature References
PubMed ID Title Journal Year
10899625 Angiotensin II generation by mast cell alpha- and beta-chymases

Wolters, PJ, Raymond, WW, Caughey, GH

Biochim Biophys Acta 2000
11502696 Functional evidence for a role of vascular chymase in the production of angiotensin II in isolated human arteries

Thuillez, C, Hurel-Merle, S, Richard, V, Scalbert, E, Lallemand, F, Bessou, JP, Ferry, G

Circulation 2001
2266130 Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart

Misono, KS, Bumpus, FM, Kinoshita, A, Husain, A, Urata, H

J Biol Chem 1990
6807977 Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases

Reilly, CF, Travis, J, Schechter, NM, Tewksbury, DA

J Biol Chem 1982
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
angiotensin maturation (0002003)
Catalyst Activity

serine-type peptidase activity of CMA1 [extracellular region]

Physical Entity
CMA1 [extracellular region] (Homo sapiens)
Activity
serine-type peptidase activity (GO:0008236)
Orthologous Events
Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Bos taurus)
Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)
Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Gallus gallus)
Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)
Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)
Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)
Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)
Authored
May, B  (2011-11-19)
Reviewed
Joseph, J  (2012-08-06)
Created
May, B  (2011-11-29)
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