Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)

Stable Identifier
R-HSA-2022383
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Chymase Hydrolyzes Angiotensin I to Yield Angiotensin II
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Chymase hydrolyzes angiotensin-(1-10) (angiotensin) to yield angiotensin-(1-8) (angiotensin II) at a higher rate than does angiotensin-converting enzyme (Reilly et al. 1982, Urata et al. 1990, Caughey et al. 2000, Richard et al. 2001).

Literature References
PubMed ID Title Journal Year
11502696 Functional evidence for a role of vascular chymase in the production of angiotensin II in isolated human arteries

Richard, V, Hurel-Merle, S, Scalbert, E, Ferry, G, Lallemand, F, Bessou, JP, Thuillez, C

Circulation 2001
10899625 Angiotensin II generation by mast cell alpha- and beta-chymases

Caughey, GH, Raymond, WW, Wolters, PJ

Biochim Biophys Acta 2000
2266130 Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart

Urata, H, Kinoshita, A, Misono, KS, Bumpus, FM, Husain, A

J Biol Chem 1990
6807977 Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases

Reilly, CF, Tewksbury, DA, Schechter, NM, Travis, J

J Biol Chem 1982
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Catalyst Activity
Title
serine-type peptidase activity of CMA1 [extracellular region]
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