Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)

Stable Identifier
R-HSA-2022381
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
Cathepsin Z (Cathepsin X) Hydrolyzes Angiotensin I to Yield Angiotensin II
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Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)
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Cathepsin Z (cathepsin X) hydrolyzes angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-8) (angiotensin II) (Nagler et al. 2010).

Literature References
PubMed ID Title Journal Year
19800993 A cysteine-type carboxypeptidase, cathepsin X, generates peptide receptor agonists

Nägler, DK, Kraus, S, Feierler, J, Mentele, R, Lottspeich, F, Jochum, M, Faussner, A

Int Immunopharmacol 2010
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
angiotensin maturation (0002003)
Catalyst Activity

cysteine-type peptidase activity of CTSZ [plasma membrane]

Physical Entity
CTSZ [plasma membrane] (Homo sapiens)
Activity
cysteine-type peptidase activity (GO:0008234)
Orthologous Events
Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Canis familiaris)
Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Danio rerio)
Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Mus musculus)
Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Rattus norvegicus)
Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Sus scrofa)
Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Xenopus tropicalis)
Authored
May, B  (2011-11-19)
Reviewed
Joseph, J  (2012-08-06)
Created
May, B  (2011-11-29)
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