Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))

Stable Identifier
R-HSA-2022381
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
Cathepsin Z (Cathepsin X) Hydrolyzes Angiotensin I to Yield Angiotensin II
ReviewStatus
5/5
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Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))
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Cathepsin Z (cathepsin X) hydrolyzes angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-8) (angiotensin II) (Nagler et al. 2010).
Literature References
PubMed ID Title Journal Year
19800993 A cysteine-type carboxypeptidase, cathepsin X, generates peptide receptor agonists

Feierler, J, Lottspeich, F, Faussner, A, Mentele, R, Kraus, S, Jochum, M, Nägler, DK

Int Immunopharmacol 2010
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
angiotensin maturation (0002003)
Catalyst Activity

cysteine-type peptidase activity of CTSZ [plasma membrane]

Physical Entity
CTSZ [plasma membrane] (Homo sapiens)
Activity
cysteine-type peptidase activity (GO:0008234)
Orthologous Events
Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) (Bos taurus)
Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) (Caenorhabditis elegans)
Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) (Canis familiaris)
Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) (Danio rerio)
Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) (Gallus gallus)
Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) (Mus musculus)
Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) (Rattus norvegicus)
Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) (Sus scrofa)
Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) (Xenopus tropicalis)
Authored
May, B  (2011-11-19)
Reviewed
Joseph, J  (2012-08-06)
Created
May, B  (2011-11-29)
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