ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)

Stable Identifier
R-HSA-2022379
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
ACE2 Hydrolyzes Angiotensin II to Yield Angiotensin-(1-7)
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Angiotensin-converting enzyme 2 (ACE2) hydrolyzes angiotensin-(1-8) (angiotensin II) to yield angiotensin-(1-7) (Vickers et al. 2002, Rice et al. 2004). The activity of ACE2 on angiotensin-(1-8) is 400-fold higher than on angiotensin-(1-10) (Vickers et al. 2002).

Literature References
PubMed ID Title Journal Year
15283675 Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism

Rice, GI, Thomas, DA, Grant, PJ, Turner, AJ, Hooper, NM

Biochem J 2004
11815627 Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase

Vickers, C, Hales, P, Kaushik, V, Dick, L, Gavin, J, Tang, J, Godbout, K, Parsons, T, Baronas, E, Hsieh, F, Acton, S, Patane, M, Nichols, A, Tummino, P

J Biol Chem 2002
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Catalyst Activity
Title
metallocarboxypeptidase activity of ACE2(18-805) [plasma membrane]
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