Reactome | ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)

ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)

Stable Identifier

R-HSA-2022379

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

ACE2(18-805):Zn2+ Hydrolyzes Angiotensin II to Yield Angiotensin-(1-7)

ReviewStatus

5/5

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ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)

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Angiotensin-converting enzyme 2 (ACE2) hydrolyzes angiotensin-(1-8) (angiotensin II) to yield angiotensin-(1-7) (Vickers et al. 2002, Rice et al. 2004). The activity of ACE2 on angiotensin-(1-8) is 400-fold higher than on angiotensin-(1-10) (Vickers et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
11815627	Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase Gavin, J, Vickers, C, Nichols, A, Acton, S, Patane, M, Godbout, K, Kaushik, V, Hales, P, Tang, J, Hsieh, F, Parsons, T, Tummino, P, Baronas, E, Dick, L	J Biol Chem	2002
15283675	Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism Hooper, NM, Turner, AJ, Grant, PJ, Thomas, DA, Rice, GI	Biochem J	2004