Phosphorylation of SLP-76

Stable Identifier
R-HSA-202216
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Phosphorylation of SLP-76
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Once SLP-76 is recruited to Gads its rapidly phosphorylated on the tyrosine residues in the N-terminal acidic domain. This domain contains three tyrosine phosphorylation sites, Y113, Y128 and Y145. These tyrosine residues are phosphorylated by tyrosine kinase ZAP-70 and these phosphorylated tyrosine residues provide the binding site for the SH2 domains of the incoming signaling proteins like Vav, Itk and PLC-gamma1.

Literature References
PubMed ID Title Journal Year
17652306 Keeping the (kinase) party going: SLP-76 and ITK dance to the beat

Qi, Q, August, A

Sci STKE 2007
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Activated ZAP-70 [plasma membrane]
Physical Entity
Activated ZAP-70 [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
Phosphorylation of SLP-76 (Bos taurus)
Phosphorylation of SLP-76 (Canis familiaris)
Phosphorylation of SLP-76 (Mus musculus)
Phosphorylation of SLP-76 (Rattus norvegicus)
Phosphorylation of SLP-76 (Sus scrofa)
Authored
Rudd, C.E.  (2008-01-24)
de Bono, B  (2008-01-24)
Garapati, P V  (2008-01-24)
Reviewed
Trowsdale, J  (2008-02-26)
Created
Garapati, P V  (2007-10-29)