Activation of ZAP-70

Stable Identifier
R-HSA-202174
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Activation of ZAP-70
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Later ZAP-70 undergoes trans-autophosphorylation at Y315 and Y319. These sites appear to be positive regulatory sites. ZAP-70 achieve its full activation after the trans-autophosphorylation. Activated ZAP-70 phosphorylates T-cell-specific adaptors, such as LAT and SLP-76 leading to the recruitment and activation of other kinase families and enzymes, resulting in secondary messenger generation and culminating in T cell activation.

Literature References
PubMed ID Title Journal Year
8520027 The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes

van Oers, NS, Weiss, A

Semin Immunol 1995
9850860 The Syk family of protein tyrosine kinases in T-cell activation and development

Chu, DH, Morita, CT, Weiss, A

Immunol Rev 1998
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of phospho tyrosine ZAP-70 [plasma membrane]
Physical Entity
phospho tyrosine ZAP-70 [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
Activation of ZAP-70 (Bos taurus)
Activation of ZAP-70 (Canis familiaris)
Activation of ZAP-70 (Mus musculus)
Activation of ZAP-70 (Rattus norvegicus)
Activation of ZAP-70 (Sus scrofa)
Activation of ZAP-70 (Xenopus tropicalis)
Authored
Rudd, C.E.  (2008-01-24)
de Bono, B  (2008-01-24)
Garapati, P V  (2008-01-24)
Reviewed
Trowsdale, J  (2008-02-26)
Created
Garapati, P V  (2007-10-29)