Activation of ZAP-70

Stable Identifier
R-HSA-202174
Type
Reaction
Species
Homo sapiens
Compartment
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Later ZAP-70 undergoes trans-autophosphorylation at Y315 and Y319. These sites appear to be positive regulatory sites. ZAP-70 achieve its full activation after the trans-autophosphorylation. Activated ZAP-70 phosphorylates T-cell-specific adaptors, such as LAT and SLP-76 leading to the recruitment and activation of other kinase families and enzymes, resulting in secondary messenger generation and culminating in T cell activation.

Literature References
PubMed ID Title Journal Year
9850860 The Syk family of protein tyrosine kinases in T-cell activation and development

Chu, DH, Morita, CT, Weiss, A

Immunol Rev 1998
8520027 The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes

van Oers, NS, Weiss, A

Semin Immunol 1995
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of phospho tyrosine ZAP-70 [plasma membrane]

Orthologous Events
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