Reactome | Phosphorylation of ZAP-70 by Lck

Phosphorylation of ZAP-70 by Lck

Stable Identifier

R-HSA-202168

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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In ZAP-70 there are multiple phosphorylation sites (Y292, Y315, Y319, Y492, Y493) which have both positive and negative regulatory effect on its catalytic activity. Tyrosine 493 is a conserved regulatory site found within the activation loop of the kinase domain. This site has shown to be a positive regulatory site required for ZAP-70 kinase activity and is phosphorylated by Lck. This phosphorylation contribute to the active conformation of the catalytic domain.

Literature References

PubMed ID	Title	Journal	Year
9850860	The Syk family of protein tyrosine kinases in T-cell activation and development Chu, DH, Morita, CT, Weiss, A	Immunol Rev	1998
8520027	The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes van Oers, NS, Weiss, A	Semin Immunol	1995