Phosphorylation of ZAP-70 by Lck

Stable Identifier
R-HSA-202168
Type
Reaction
Species
Homo sapiens
Compartment
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In ZAP-70 there are multiple phosphorylation sites (Y292, Y315, Y319, Y492, Y493) which have both positive and negative regulatory effect on its catalytic activity. Tyrosine 493 is a conserved regulatory site found within the activation loop of the kinase domain. This site has shown to be a positive regulatory site required for ZAP-70 kinase activity and is phosphorylated by Lck. This phosphorylation contribute to the active conformation of the catalytic domain.

Literature References
PubMed ID Title Journal Year
9850860 The Syk family of protein tyrosine kinases in T-cell activation and development

Chu, DH, Morita, CT, Weiss, A

Immunol Rev 1998
8520027 The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes

van Oers, NS, Weiss, A

Semin Immunol 1995
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]

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