AKT1 phosphorylates eNOS

Stable Identifier
R-HSA-202111
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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HSP90 serves as a scaffold to promote productive interaction between AKT1 and eNOS. Due to the proximity of these proteins once complexed with HSP90, AKT1 phosphorylates eNOS at Ser1177. When Ser1177 is phosphorylated, the level of NO production is elevated two- to three-fold above basal level.

Literature References
PubMed ID Title Journal Year
10469573 The Akt kinase signals directly to endothelial nitric oxide synthase

Michell, BJ, Griffiths, JE, Mitchelhill, KI, Rodriguez-Crespo, I, Tiganis, T, Bozinovski, S, de Montellano, PR, Kemp, BE, Pearson, RB

Curr Biol 1999
10376602 Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

Fulton, D, Gratton, JP, McCabe, TJ, Fontana, J, Fujio, Y, Walsh, K, Franke, TF, Papapetropoulos, A, Sessa, WC

Nature 1999
10376603 Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

Dimmeler, S, Fleming, I, Fisslthaler, B, Hermann, C, Busse, R, Zeiher, AM

Nature 1999
Participants
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