AKT1 phosphorylates eNOS

Stable Identifier
Reaction [transition]
Homo sapiens
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HSP90 serves as a scaffold to promote productive interaction between AKT1 and eNOS. Due to the proximity of these proteins once complexed with HSP90, AKT1 phosphorylates eNOS at Ser1177. When Ser1177 is phosphorylated, the level of NO production is elevated two- to three-fold above basal level.

Literature References
PubMed ID Title Journal Year
10376602 Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

Fontana, J, Sessa, WC, Franke, TF, Walsh, K, Fulton, D, Gratton, JP, Fujio, Y, Papapetropoulos, A, McCabe, TJ

Nature 1999
10469573 The Akt kinase signals directly to endothelial nitric oxide synthase

Pearson, RB, Bozinovski, S, Rodriguez-Crespo, I, Griffiths, JE, de Montellano, PR, Kemp, BE, Tiganis, T, Mitchelhill, KI, Michell, BJ

Curr Biol 1999
10376603 Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

Hermann, C, Zeiher, AM, Fleming, I, Fisslthaler, B, Busse, R, Dimmeler, S

Nature 1999
Orthologous Events
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