eNOS:Caveolin-1 complex binds to CaM

Stable Identifier
R-HSA-202110
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
eNOS:Caveolin-1 complex binds to CaM
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Caveolin inhibition of eNOS is relieved by calmodulin, the first step in the dissociation of eNOS from caveolin (Kone at al. 2003; Michel et al. 1997).
Literature References
PubMed ID Title Journal Year
9188442 Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin

Michel, JB, Feron, O, Sacks, D, Michel, T

J Biol Chem 1997
12842859 Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide

Kone, BC, Kuncewicz, T, Zhang, W, Yu, ZY

Am J Physiol Renal Physiol 2003
Participants
Input
Output
Participates
as an event of
Catalyst Activity

calmodulin binding activity of eNOS:Caveolin-1 [plasma membrane]

Physical Entity
eNOS:Caveolin-1 [plasma membrane] (Homo sapiens)
Activity
calmodulin binding (GO:0005516)
Orthologous Events
eNOS:Caveolin-1 complex binds to CaM (Bos taurus)
eNOS:Caveolin-1 complex binds to CaM (Mus musculus)
eNOS:Caveolin-1 complex binds to CaM (Rattus norvegicus)
Authored
Hemish, J  (2007-10-19)
Reviewed
Enikolopov, G  (2008-02-28)
Hill, DP  (2024-08-02)
Created
Hemish, J  (2007-10-19)
Cite Us!