Inactive catalytic PP2B is activated by the binding of calmodulin

Stable Identifier
R-HSA-201783
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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PP2B (calcineurin) is a calcium-dependent, calmodulin-stimulated protein phosphatase. It comprises of two components; a catalytic subunit and a regulatory subunit which confers calcium sensitivity to the complex. PP2B is in equilibrium between active and inactive forms. Because the affinity of calmodulin for the active form is higher than for the inactive form, it stabilises PP2B.
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