CSNK2-mediated phosphorylation of DVL

Stable Identifier
Reaction [transition]
Homo sapiens
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DVL proteins from Drosophila, Xenopus, mouse and human cells have been shown to be phosphorylated, however the role of phosphorylation remains incompletely understood (Willert et al, 1997; Semenov and Synder, 1997; Yanagawa et al, 1995; Rothbächer et al, 2000). CSNK2 was identified as a DVL-associated kinase in Drosophila cells, and was shown to mediate the phosphorylation of serine and threonine residues in vitro (Willert et al, 1997). CSNK2-mediated phosphorylation of DVL may be constitutive, as DVL exists as a phosphoprotein even in the absence of WNT signaling (Bernatik et al, 2011). The association between DVL and CSNK2 may be enhanced upon WNT signaling, leading to increased levels of DVL phosphorylation (Willert et al, 2007).

Literature References
PubMed ID Title Journal Year
7744250 The dishevelled protein is modified by wingless signaling in Drosophila

Yanagawa, S, Klingensmith, J, Wodarz, A, Nusse, R, van Leeuwen, F

Genes Dev. 1995
10698942 Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis

Laurent, MN, Rothbächer, U, Klein, PS, Deardorff, MA, Cho, KW, Fraser, SE

EMBO J. 2000
9214626 Casein kinase 2 associates with and phosphorylates dishevelled

Varmus, H, Wodarz, A, Nusse, R, Willert, K, Brink, M

EMBO J. 1997
9192851 Human dishevelled genes constitute a DHR-containing multigene family

Semënov, MV, Snyder, M

Genomics 1997
21285348 Sequential activation and inactivation of Dishevelled in the Wnt/beta-catenin pathway by casein kinases

Polonio, T, Schulte, G, Bernatik, O, Bryja, V, Konik, P, Ganji, RS, Krejci, P, Cervenka, I, Dijksterhuis, JP

J. Biol. Chem. 2011
Catalyst Activity

protein serine/threonine kinase activity of Casein kinase II [cytosol]

Orthologous Events
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