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ZFYVE16 [early endosome membrane]
Stable Identifier
R-HSA-201645
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
early endosome membrane
Synonyms
Endofin, Zinc finger FYVE domain-containing protein 16, ZY16_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by BMP (Homo sapiens)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Homo sapiens)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Homo sapiens)
ZFYVE16 [early endosome membrane] (Homo sapiens)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Homo sapiens)
ZFYVE16 [early endosome membrane] (Homo sapiens)
An anchoring protein, Endofin, recruits R-Smad1/5/8 (Homo sapiens)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Homo sapiens)
ZFYVE16 [early endosome membrane] (Homo sapiens)
ZFYVE16 [early endosome membrane] (Homo sapiens)
Phospho-R-Smad1/5/8 dissociates from the receptor complex (Homo sapiens)
BMP:p-BMPR:Endofin [early endosome membrane] (Homo sapiens)
ZFYVE16 [early endosome membrane] (Homo sapiens)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Homo sapiens)
ZFYVE16 [early endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q7Z3T8 ZFYVE16
Gene Names
ZFYVE16, KIAA0305
Chain
chain:1-1539
Reference Genes
BioGPS Gene:9765 ZFYVE16
COSMIC (genes):ZFYVE16 ZFYVE16
CTD Gene:9765 ZFYVE16
dbSNP Gene:9765 ZFYVE16
ENSEMBL:ENSG00000039319 ZFYVE16
HGNC:20756 ZFYVE16
KEGG:hsa:9765 ZFYVE16
Monarch:9765 ZFYVE16
NCBI Gene:9765 ZFYVE16
OMIM:608880 ZFYVE16
UCSC:Q7Z3T8 ZFYVE16
Reference Transcript
RefSeq:XM_011543753.2 ZFYVE16
RefSeq:NM_001284237.1 ZFYVE16
RefSeq:XM_017010092.1 ZFYVE16
RefSeq:XM_005248632.4 ZFYVE16
RefSeq:XM_017010091.1 ZFYVE16
Other Identifiers
11739855_a_at
11750632_a_at
11754534_a_at
1554638_PM_at
1554638_at
1555011_PM_at
1555011_at
16986700
203651_PM_at
203651_at
240859_PM_at
240859_at
2817732
2817735
2817736
2817737
2817740
2817741
2817742
2817743
2817744
2817745
2817746
2817747
2817748
2817750
2817751
2817752
2817753
2817755
2817756
2817757
2817758
2817759
2817760
2817761
2817762
2817763
2817764
2817765
2817766
2817767
2817768
2817769
2817770
2817772
2817775
2817777
2817778
2817779
2817782
2817784
2817785
2817786
2817787
2817788
2817789
2817790
2817792
2817794
2817795
2817796
2817797
37914_at
42259_at
53107_at
8106602
9765
A_14_P103626
A_14_P125384
A_14_P139609
A_23_P7543
A_24_P239531
A_24_P286054
A_24_P8349
GE528248
GE53044
GO:0005515
GO:0005545
GO:0005547
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0006622
GO:0006886
GO:0007165
GO:0008289
GO:0016020
GO:0016050
GO:0016192
GO:0016197
GO:0030100
GO:0031410
GO:0031901
GO:0043226
GO:0043231
GO:0046872
HMNXSV003032437
HMNXSV003048716
Hs.42568.0.S1_3p_at
Hs2.83790.3.S1_3p_at
ILMN_1651769
ILMN_2140999
PH_hs_0025659
TC05000398.hg
g7662047_3p_at
Participates
as an input of
An anchoring protein, Endofin, recruits R-Smad1/5/8 (Homo sapiens)
as a component of
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Homo sapiens)
BMP:p-BMPR:Endofin [early endosome membrane] (Homo sapiens)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Homo sapiens)
Inferred To
Sara [early endosome membrane]
(Drosophila melanogaster)
zfyve16 [early endosome membrane]
(Danio rerio)
zfyve16 [early endosome membrane]
(Xenopus tropicalis)
aka-1 [early endosome membrane]
(Caenorhabditis elegans)
ZFYVE16 [early endosome membrane]
(Bos taurus)
ZFYVE16 [early endosome membrane]
(Canis familiaris)
ZFYVE16 [early endosome membrane]
(Gallus gallus)
ZFYVE16 [early endosome membrane]
(Mus musculus)
ZFYVE16 [early endosome membrane]
(Sus scrofa)
Zfyve16 [early endosome membrane]
(Rattus norvegicus)
Cross References
RefSeq
XP_011542055.1
,
XP_016865581.1
,
XP_005248689.1
,
NP_001271166.1
,
XP_016865580.1
ENSEMBL
ENST00000510158
,
ENSP00000423663
,
ENSP00000337159
,
ENST00000338008
,
ENST00000505560
,
ENSP00000426848
OpenTargets
ENSG00000039319
HPA
ENSG00000039319-ZFYVE16
PRO
Q7Z3T8
Pharos - Targets
Q7Z3T8
GlyGen
Q7Z3T8
PDB
5MK0
,
3T7L
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60784 TOM1
3
TOM1 [specific granule membrane]
(R-HSA-6800923)
TOM1 [plasma membrane]
(R-HSA-6806274)
TOM1 [azurophil granule membrane]
(R-HSA-6799348)
0.736
6
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.659
3
UniProt:Q15075 EEA1
1
EEA1 [endosome membrane]
(R-HSA-187893)
0.536
4
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