Caspase-mediated cleavage of Desmoplakin

Stable Identifier
R-HSA-201636
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cleavage of desmosomal proteins including desmoplakin contributes to cell rounding and disintegration of the intermediate filament system (Weiske et al., 2001). Caspase-3 inhibition prevents desmoplakin cleavage, implicating caspase-3 as the responsible endopeptidase (Weiske et al. 2001).

Literature References
PubMed ID Title Journal Year
11500511 The fate of desmosomal proteins in apoptotic cells

Weiske, J, Schoneberg, T, Schroder, W, Hatzfeld, M, Tauber, R, Huber, O

J Biol Chem 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created