Caspase-mediated cleavage of Desmoglein 3

Stable Identifier
R-HSA-201631
Type
Reaction
Species
Homo sapiens
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In epithelial cells, desmosomes are anchoring junctions that mediate strong cell-cell contacts. Desmosomal proteins are proteolytically targeted during apoptosis (Weiske et al., 2001). Desmogleins are a major component of the desmosome are specifically cleaved after onset of apoptosis. Cleavage of desmosomal proteins results in the disruption of the structure of desmosomes and contributes to cell rounding and disassembly of the intermediate filament network (Weiske et al., 2001). The cytosolic fragment has implications for the autoimmune disease, Pemphigus vulgaris (Tong et al. 2006).

Literature References
PubMed ID Title Journal Year
11500511 The fate of desmosomal proteins in apoptotic cells

Weiske, J, Tauber, R, Schroder, W, Hatzfeld, M, Schoneberg, T, Huber, O

J Biol Chem 2001
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Participates
Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3 [cytosol]

Orthologous Events
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