Caspase-mediated cleavage of gelsolin

Stable Identifier
R-HSA-201622
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Gelsolin is cleaved by caspase-3 generating a constitutively
active fragment that can depolymerize F-actin contributing to actin cytoskeletal collapse (Kothakota et al., 1997)

Literature References
PubMed ID Title Journal Year
9323209 Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis

Koths, K, McGarry, TJ, Kwiatkowski, DJ, Klippel, A, Tang, J, Kothakota, S, Kirschner, MW, Reinhard, C, Chu, K, Azuma, T, Williams, LT

Science 1997
9930654 Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines

Libby, P, Kwiatkowski, DJ, Wu, Q, Hartwig, JH, Muszynski, M, Geng, YJ, Tang, JX, Azuma, T

Eur J Cell Biol 1998
Participants
Participates
Catalyst Activity

cysteine-type endopeptidase activity of Caspase-3 [cytosol]

Orthologous Events
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