Reactome | I-Smad competes with R-Smad1/5/8 for type I receptor

I-Smad competes with R-Smad1/5/8 for type I receptor

Stable Identifier

R-HSA-201475

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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I-Smad competes with R-Smad1/5/8 for type I receptor

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I-SMADs reside in the nucleus presumably to be sequestered from the BMP2:receptor complex and thus avoid inappropriate silencing of the signalling pathway. Upon activation of the signalling pathway, I-SMADs exit the nucleus and are recruited to the signalling BMP2:receptor complex. I-SMADs directly bind to the so-called L45 loop of the type I receptor, the site of binding of R-SMADs. Thus, I-SMADs competitively inhibit the activation/phosphorylation of R-SMADs.

Literature References

PubMed ID	Title	Journal	Year
12857866	Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads Miyazono, K, Murakami, G, Imamura, T, Takaoka, K, Watabe, T	Mol Biol Cell	2003
12519765	Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7 Yoshida, M, Miyazono, K, Yoneda, Y, Tajima, Y, Shinomiya, K, Goto, K, Sekimoto, T, Imamura, T	J Biol Chem	2003